Overview
Chelates copper at tyrosinase active site, inhibits MSH signaling, and neutralizes UV-induced ROS.
Proposed mechanism
Hexapeptide-9 is a bilberry-derived peptide that inhibits tyrosinase and scavenges free radicals while reducing inflammatory pigmentation signals.
What the evidence supports
Human data exists but the trials are small, short-term, or not yet replicated.
Graded Human-limited
Human data that exists but is thin: open-label work, single-arm studies, small cohorts, or observational follow-up without randomisation.
Key citations
Representative primary sources, including results that did not favour the compound.
- [1]
Bilberry peptide for pigmentation
· DOI:10.1111/jocd.12981 · 2019
- [2]
Natural skin lighteners
· DOI:10.1111/jocd.13185 · 2020
- [3]
Bilberry peptide for pigmentation (2019)
· · 0
- [4]
Natural skin lighteners (2020)
· · 0
Citation records in this build are illustrative placeholders for the design.
Reference information for research purposes. Not medical advice, and not a recommendation to use any compound. Many entries describe substances that are not approved for human use.