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AnecdotalMitochondrial peptide for brain protection

Humanin

Mitochondrial-derived neuroprotective peptide.

Overview

Binds to receptors (CNTFR/WSX-1) and activates survival signaling pathways (STAT3, AKT) while blocking pro-apoptotic Bax.

Proposed mechanism

Humanin is a 24-amino acid mitochondrial-derived peptide that binds to STAT3 and IGFBP-3, inhibiting apoptosis and reducing amyloid-beta toxicity.

What the evidence supports

Evidence rests primarily on self-reported experience. Controlled studies are lacking.

Graded Anecdotal

Case reports, clinician notes, and user-reported outcomes. Recorded for completeness and labelled plainly so it is never mistaken for data.

Key citations

Representative primary sources, including results that did not favour the compound.

  1. [1]

    Humanin in AD

    · DOI:10.1038/s41582-018-0107-5 · 2018

  2. [2]

    Mitochondrial peptides

    · DOI:10.1038/s41467-020-19392-7 · 2020

  3. [3]

    Humanin in AD (2018)

    · · 0

  4. [4]

    Mitochondrial peptides (2020)

    · · 0

Citation records in this build are illustrative placeholders for the design.

Reference information for research purposes. Not medical advice, and not a recommendation to use any compound. Many entries describe substances that are not approved for human use.

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