Peptide profile
Humanin
Mitochondrial peptide for brain protection
Compare Humanin with other peptides →Summary
A tiny body protein that helps protect your brain.
- Typical dose
- 5-15mg Daily
- Route
- Subcutaneous
- Cycle length
- 30-90 days
- Evidence
- Anecdotal
Mechanism
How it works
Humanin acts like a bodyguard for brain cells — it intercepts toxic amyloid-beta proteins and prevents them from triggering cell death.
Humanin is a 24-amino acid mitochondrial-derived peptide that binds to STAT3 and IGFBP-3, inhibiting apoptosis and reducing amyloid-beta toxicity.
Reported in research
Benefits
- May help protect against memory loss like Alzheimer's
- Helps keep brain cells from dying too soon
- Helps the tiny power plants inside cells work better
- Helps calm down swelling in the brain
Context, not a prescription
Dosing
- Typical range
- 5-15mg Daily (Subcutaneous)
- Cycle length
- 30-90 days
Safety
Side effects & contraindications
Possible side effects
- Injection site pain
- Mild fatigue
- Headache
- Unknown (limited human data)
Contraindications
- Pregnancy or breastfeeding
- Autoimmune neurological conditions
Research information, not medical advice. Always consult a licensed clinician before considering any peptide.
In depth
Full profile
What it does
May protect your brain, slow memory loss, and help your cells' power plants stay healthy.
How it works
Humanin is like a bodyguard for your brain cells. It stops harmful sticky proteins from hurting them.
It sticks to special spots on cells. This turns on signals that help cells survive. It also blocks a part that tells cells to die.
What to expect
No quick effects. The protection builds up over a long time.
- Weeks 2-4: Small brain-protecting effects start.
- Weeks 6-8: Your thinking may stay steady.
- Weeks 10-12: Best help for your cells' power plants.
Good to know
- Use only in research, not on your own
- Start with the smallest dose
Staying safe
- Pain where you get the shot
- Feeling a little tired
- Headache
Avoid if you have:
- People who are pregnant or breastfeeding
- People whose immune system attacks their own nerves
Mechanism of action
Humanin is a 24-amino acid mitochondrial-derived peptide that binds to STAT3 and IGFBP-3, inhibiting apoptosis and reducing amyloid-beta toxicity.
Binds to receptors (CNTFR/WSX-1) and activates survival signaling pathways (STAT3, AKT) while blocking pro-apoptotic Bax.
Pharmacodynamics
No acute effects; long-term protective benefits.
Potential neuroprotection, reduced cognitive decline, improved mitochondrial health.
Timeline
- Weeks 2-4: Subtle neuroprotective effects.
- Weeks 6-8: Potential cognitive stabilization.
- Weeks 10-12: Maximum mitochondrial benefits.
Comparisons
- Humanin — effectiveness Emerging, safety Unknown, cost $$$, Hard to use
- SS-31 — effectiveness Emerging, safety Good, cost $$$, Medium to use
Adverse effects
Common:
- Injection site pain
- Mild fatigue
- Headache
Rare:
- Unknown (limited human data)
Contraindications & risk mitigation
Contraindicated in:
- Pregnancy or breastfeeding
- Autoimmune neurological conditions
- Use only in research settings
- Start with lowest dose
Qué hace
Puede proteger tu cerebro, ralentizar la pérdida de memoria y ayudar a que las centrales de energía de tus células se mantengan saludables.
Cómo funciona
Humanin es como un guardaespaldas para tus células cerebrales. Evita que las proteínas pegajosas dañinas las lastimen.
Se adhiere a puntos especiales en las células. Esto activa señales que ayudan a las células a sobrevivir. También bloquea una parte que indica a las células que deben morir.
Qué esperar
Sin efectos rápidos. La protección se acumula con el tiempo.
- Semanas 2-4: Comienzan los efectos protectores del cerebro.
- Semanas 6-8: Tu capacidad de pensamiento puede mantenerse estable.
- Semanas 10-12: La mejor ayuda para las centrales de energía de tus células.
Bueno saber
- Usar solo en investigación, no por cuenta propia
- Comenzar con la dosis más pequeña
Manteniéndose seguro
- Dolor donde te aplican la inyección
- Sentirse un poco cansado
- Dolor de cabeza
Evitar si tienes:
- Personas que están embarazadas o en periodo de lactancia
- Personas cuyo sistema inmunológico ataca sus propios nervios
Mecanismo de acción
Humanin es un péptido mitocondrial derivado de 24 aminoácidos que se une a STAT3 e IGFBP-3, inhibiendo la apoptosis y reduciendo la toxicidad de la beta-amiloide.
Se une a receptores (CNTFR/WSX-1) y activa vías de señalización de supervivencia (STAT3, AKT) mientras bloquea Bax proapoptótico.
Farmacodinamia
Sin efectos agudos; beneficios protectores a largo plazo.
Neuroprotección potencial, reducción del deterioro cognitivo, mejora de la salud mitocondrial.
Cronología
- Semanas 2-4: Efectos neuroprotectores sutiles.
- Semanas 6-8: Estabilización cognitiva potencial.
- Semanas 10-12: Beneficios mitocondriales máximos.
Comparaciones
- Humanin — efectividad Emergente, seguridad Desconocida, costo $$$, Difícil de usar
- SS-31 — efectividad Emergente, seguridad Buena, costo $$$, Media de usar
Efectos adversos
Comunes:
- Dolor en el sitio de inyección
- Fatiga leve
- Dolor de cabeza
Raros:
- Desconocido (datos humanos limitados)
Contraindicaciones y mitigación de riesgos
Contraindicado en:
- Embarazo o lactancia
- Trastornos neurológicos autoinmunes
- Usar solo en entornos de investigación
- Comenzar con la dosis más baja
Reference data
Specifications
- Route
- Subcutaneous
- Cycle length
- 30-90 days
FAQ
Common questions
Is Humanin FDA-approved?
No, it is investigational with limited human trials.
Does it work for Alzheimer's?
Promising in animal models; human data is preliminary.
What is the evidence level?
This compound is classified as Anecdotal. Evidence relies primarily on self-reported user experiences. Controlled studies are lacking.
Research
Research & sources
Current evidence for Humanin is rated as Anecdotal. No controlled clinical research is available.
- 1. Humanin in AD (2018) — DOI:10.1038/s41582-018-0107-5
- 2. Mitochondrial peptides (2020) — DOI:10.1038/s41467-020-19392-7
- 3. Humanin in AD (2018)
- 4. Mitochondrial peptides (2020)