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AnecdotalActive fragment of neuroprotective protein ADNP

NAPVSIPQ (ADNP fragment)

Activity-dependent neuroprotective peptide fragment.

Overview

Interacts with tubulin and microtubule-associated protein tau, reduces hyperphosphorylation, and promotes neurite outgrowth.

Proposed mechanism

NAPVSIPQ is the core active motif of ADNP (activity-dependent neuroprotective protein), which binds to microtubules and interacts with tau to maintain cytoskeletal integrity.

What the evidence supports

Evidence rests primarily on self-reported experience. Controlled studies are lacking.

Graded Anecdotal

Case reports, clinician notes, and user-reported outcomes. Recorded for completeness and labelled plainly so it is never mistaken for data.

Key citations

Representative primary sources, including results that did not favour the compound.

  1. [1]

    ADNP fragment neuroprotection

    · DOI:10.1073/pnas.0905515106 · 2009

  2. [2]

    NAP peptide tau interaction

    · DOI:10.1016/j.jmb.2011.03.064 · 2011

  3. [3]

    ADNP fragment neuroprotection (2009)

    · · 0

  4. [4]

    NAP peptide tau interaction (2011)

    · · 0

Citation records in this build are illustrative placeholders for the design.

Reference information for research purposes. Not medical advice, and not a recommendation to use any compound. Many entries describe substances that are not approved for human use.

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