Peptide profile
Peptide YY (PYY 3-36)
Endogenous Y2 receptor agonist for satiety
Compare Peptide YY (PYY 3-36) with other peptides →Summary
A natural body helper that makes you feel less hungry.
- Typical dose
- 50-200mcg 1-2x daily before meals
- Route
- Subcutaneous, Nasal
- Cycle length
- 4-12 weeks
- Evidence
- Animal data
Mechanism
How it works
PYY acts like a 'stop eating' signal from your gut to your brain — when your small intestine senses food, it releases this peptide to tell your brain you're full.
PYY 3-36 is a naturally occurring gut hormone that binds to Y2 receptors in the hypothalamus (arcuate nucleus), reducing NPY release and appetite.
Reported in research
Benefits
- Helps you feel less hungry for 6-12 hours
- Helps you feel full after eating
- May help your body handle sugar better
- Helped people eat less food in studies
Context, not a prescription
Dosing
- Typical range
- 50-200mcg 1-2x daily before meals (Subcutaneous, Nasal)
- Cycle length
- 4-12 weeks
Safety
Side effects & contraindications
Possible side effects
- Nausea
- Mild abdominal cramping
- Headache
- Vomiting
- Diarrhea
- Injection site reaction
Contraindications
- Pregnancy or breastfeeding
- Eating disorders
- Gastrointestinal obstruction history
Research information, not medical advice. Always consult a licensed clinician before considering any peptide.
In depth
Full profile
What it does
You feel less hungry. You eat smaller meals. You stay full longer between meals.
How it works
PYY is like a 'stop eating' message from your gut to your brain. When your gut feels food, it sends this message to say you're full.
It connects to special spots on brain cells. This turns off the 'I'm hungry' signal. So you eat less food.
What to expect
You feel less hungry in 30-60 minutes. It lasts 6-12 hours.
- Day 1: You feel less hungry right after the shot.
- Weeks 2-3: You slowly start eating less each day.
- Weeks 4-8: You keep losing weight little by little.
Good to know
- Start with the smallest dose (50mcg)
- Take it before your biggest meal
- Watch out if you feel too sick to your stomach
Staying safe
- Feeling sick to your stomach
- Mild belly cramps
- Headache
Avoid if you have:
- People who are pregnant or breastfeeding
- People with eating troubles
- People who have had a blocked gut before
Mechanism of action
PYY 3-36 is a naturally occurring gut hormone that binds to Y2 receptors in the hypothalamus (arcuate nucleus), reducing NPY release and appetite.
Binds to Y2 receptors on NPY/AgRP neurons in the hypothalamus, inhibiting orexigenic signaling and reducing food intake.
Pharmacodynamics
Appetite reduction within 30-60 minutes; lasts 6-12 hours.
Reduced hunger, smaller meal sizes, prolonged satiety between meals.
Timeline
- Day 1: Immediate appetite reduction after injection.
- Weeks 2-3: Gradual reduction in daily calorie intake.
- Weeks 4-8: Progressive weight loss.
Comparisons
- PYY 3-36 — effectiveness Moderate, safety Emerging, cost $$$, Hard to use
- Semaglutide — effectiveness Very High, safety Good, cost $$$, Easy to use
Adverse effects
Common:
- Nausea
- Mild abdominal cramping
- Headache
Rare:
- Vomiting
- Diarrhea
- Injection site reaction
Contraindications & risk mitigation
Contraindicated in:
- Pregnancy or breastfeeding
- Eating disorders
- Gastrointestinal obstruction history
- Start with lowest dose (50mcg)
- Inject before largest meal
- Monitor for excessive nausea
Qué hace
Sientes menos hambre. Comes porciones más pequeñas. Te mantienes lleno por más tiempo entre comidas.
Cómo funciona
PYY es como un mensaje de 'deja de comer' desde tu intestino hacia tu cerebro. Cuando tu intestino detecta alimento, envía este mensaje para indicar que estás lleno.
Se conecta a puntos especiales en las células del cerebro. Esto apaga la señal de 'tengo hambre'. Así que comes menos.
Qué esperar
Sientes menos hambre en 30-60 minutos. El efecto dura 6-12 horas.
- Día 1: Sientes menos hambre justo después de la inyección.
- Semanas 2-3: Comienzas a comer menos poco a poco cada día.
- Semanas 4-8: Sigues perdiendo peso poco a poco.
Bueno saber
- Comenzar con la dosis más pequeña (50 mcg)
- Tomarlo antes de tu comida más abundante
- Vigilar si sientes náuseas excesivas
Manteniéndose seguro
- Molestias estomacales
- Cólicos abdominales leves
- Dolor de cabeza
Evitar si tienes:
- Personas embarazadas o en lactancia
- Personas con problemas alimentarios
- Personas que han tenido un bloqueo intestinal antes
Mecanismo de acción
PYY 3-36 es una hormona intestinal natural que se une a los receptores Y2 en el hipotálamo (núcleo arqueado), reduciendo la liberación de NPY y el apetito.
Se une a los receptores Y2 en las neuronas NPY/AgRP del hipotálamo, inhibiendo la señalización orexigénica y reduciendo la ingesta de alimentos.
Farmacodinamia
Reducción del apetito en 30-60 minutos; dura 6-12 horas.
Menor hambre, porciones más pequeñas, saciedad prolongada entre comidas.
Cronología
- Día 1: Reducción inmediata del apetito después de la inyección.
- Semanas 2-3: Reducción gradual de la ingesta calórica diaria.
- Semanas 4-8: Pérdida de peso progresiva.
Comparaciones
- PYY 3-36 — efectividad Moderada, seguridad Emergente, costo $$$, Difícil de usar
- Semaglutida — efectividad Muy Alta, seguridad Buena, costo $$$, Fácil de usar
Efectos adversos
Comunes:
- Náuseas
- Cólicos abdominales leves
- Dolor de cabeza
Raros:
- Vómitos
- Diarrea
- Reacción en el sitio de inyección
Contraindicaciones y mitigación de riesgos
Contraindicado en:
- Embarazo o lactancia
- Trastornos alimentarios
- Antecedentes de obstrucción gastrointestinal
- Comenzar con la dosis más baja (50 mcg)
- Inyectar antes de la comida más abundante
- Vigilar náuseas excesivas
Reference data
Specifications
- Route
- Subcutaneous, Nasal
- Cycle length
- 4-12 weeks
FAQ
Common questions
Is PYY safe long-term?
Limited long-term data; short-term studies show good tolerability.
Can it be taken orally?
No, oral bioavailability is poor; injection or intranasal required.
What is the evidence level?
This compound is classified as Animal data. Most data comes from preclinical animal studies. Human clinical trial evidence is limited or absent.
Research
Research & sources
Current evidence for Peptide YY (PYY 3-36) is rated as Animal data. Research is based primarily on animal models.
- 1. PYY 3-36 in obesity (2003) — DOI:10.1056/NEJMoa023200
- 2. PYY pharmacology (2016) — DOI:10.1038/nrd.2016.100
- 3. PYY 3-36 in obesity (2003)
- 4. PYY pharmacology (2016)