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AnimalSystemic healing for wounds, tendons, and gut

BPC-157

Also indexed as Body Protection Compound-157, PL 14736

A synthetic pentadecapeptide derived from a protein in gastric juice, studied for tissue repair, gut protection, and musculoskeletal healing.

Overview

Binds to growth factor receptors and promotes cell migration to damaged tissues.

Proposed mechanism

Thought to upregulate growth factor receptors (VEGFR2, EGF), promote angiogenesis, and modulate the nitric oxide system to accelerate healing.

What the evidence supports

Most data comes from preclinical animal studies. Human clinical trial evidence is limited or absent.

Graded Animal

Evidence drawn from in vivo animal models or in vitro systems. Mechanistically informative; translation to humans is unproven.

Key citations

Representative primary sources, including results that did not favour the compound.

  1. [1]

    Stable gastric pentadecapeptide BPC-157

    · DOI:10.3390/ph13090268 · 2020

  2. [2]

    BPC-157 and wound healing

    · DOI:10.1111/j.1749-6632.2009.05124.x · 2010

  3. [3]

    Sikiric et al. — BPC-157 review on tissue repair

    · · 0

  4. [4]

    Chang et al. — BPC-157 and tendon healing

    · · 0

Citation records in this build are illustrative placeholders for the design.

Reference information for research purposes. Not medical advice, and not a recommendation to use any compound. Many entries describe substances that are not approved for human use.

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