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AnimalThymosin beta-4 fragment for wound repair

TB-500

Also indexed as Thymosin Beta-4 fragment, Tβ4 fragment

A synthetic fragment of Thymosin Beta-4, a naturally occurring protein involved in actin regulation, tissue repair, and inflammation modulation.

Overview

Promotes endothelial cell migration and differentiation into new blood vessels.

Proposed mechanism

Binds to actin and promotes cell migration, angiogenesis, and upregulation of repair-related growth factors including IGF-1 and HGF.

What the evidence supports

Most data comes from preclinical animal studies. Human clinical trial evidence is limited or absent.

Graded Animal

Evidence drawn from in vivo animal models or in vitro systems. Mechanistically informative; translation to humans is unproven.

Key citations

Representative primary sources, including results that did not favour the compound.

  1. [1]

    Thymosin beta-4 and wound healing

    · DOI:10.1111/j.1749-6632.2007.tb00465.x · 2007

  2. [2]

    TB-500 in tissue regeneration

    · DOI:10.1586/17434440.2.6.729 · 2005

  3. [3]

    Goldstein et al. — Thymosin Beta-4 and tissue repair

    · · 0

  4. [4]

    Sosne et al. — Thymosin Beta-4 anti-inflammatory effects

    · · 0

Citation records in this build are illustrative placeholders for the design.

Reference information for research purposes. Not medical advice, and not a recommendation to use any compound. Many entries describe substances that are not approved for human use.

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