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The library

149 compounds. Every one graded.

Filter by research area or by how strong the evidence actually is. Profiles graded Animal or Anecdotal are not hidden they are labelled, which is more useful.

Clinical
15
Human-limited
61
Animal
54
Anecdotal
19

15 of 149 profiles

Focus & Memory

Oxytocin Acetate

Clinical

The bonding hormone for trust and connection

Oxytocin Acetate is the acetate salt form of oxytocin, a naturally occurring nonapeptide hormone synthesized in the hypothalamus and released by the posterior pituitary gland. It plays central roles in social bonding, trust, stress reduction, sexual function, and uterine contraction. Research has expanded its potential applications to include anxiety reduction, prosocial behavior enhancement, and modulation of the hypothalamic-pituitary-adrenal (HPA) axis.

0 RCT · 0 human · 0 preclinical

mood

Selank

Human-limited

Anxiolytic peptide for calm focus and immune support

A synthetic heptapeptide derived from the immunomodulatory peptide tuftsin, developed in Russia for anxiolytic and nootropic effects without the sedation or dependence of benzodiazepines.

0 RCT · 0 human · 0 preclinical

cognition

Cerebrolysin

Animal

Neurotrophic peptide blend for cognitive repair

Neurotrophic peptide mix for brain repair & cognitive recovery.

0 RCT · 0 human · 0 preclinical

cognition

Cortagen

Animal

Pineal-derived peptide for brain and immunity

Cortagen is a synthetic tetrapeptide (Ala-Glu-Asp-Pro) derived from the pineal gland and developed within the Russian peptide bioregulator program. It is primarily studied for its neuroprotective and immunomodulatory properties, with research suggesting it may support cortical function, slow age-related neurological decline, and modulate immune responses. Most of its evidence base comes from Russian preclinical and limited clinical studies conducted in the 1980s–2000s.

0 RCT · 0 human · 0 preclinical

cognition

Crystagen

Animal

Ocular cytoprotection via crystallin chaperone mimicry

Crystagen is a synthetic peptide derived from the alpha-crystallin protein family, small heat-shock proteins (sHSPs) naturally abundant in the eye lens. It is investigated primarily for its cytoprotective and anti-apoptotic properties in ocular tissues, with emerging research suggesting neuroprotective and anti-inflammatory effects. Evidence is largely limited to animal and in vitro models, and no approved clinical use currently exists.

0 RCT · 0 human · 0 preclinical

eye

Dermorphin

Animal

Ultra-potent frog-derived mu-opioid peptide

Dermorphin is a naturally occurring heptapeptide opioid first isolated from the skin secretions of South American phyllomedusa frogs. It binds with extraordinarily high selectivity and affinity to mu-opioid receptors, producing potent analgesic and sedative effects estimated to be 30–40 times more potent than morphine on a molar basis. Its unique structure incorporates a D-amino acid (D-Ala), which confers resistance to enzymatic degradation and prolongs its biological activity.

0 RCT · 0 human · 0 preclinical

mood

Orexin B

Animal

Wakefulness neuropeptide driving arousal and cognition

Orexin B (also known as Hypocretin-2) is a neuropeptide produced in the lateral hypothalamus that plays a central role in regulating wakefulness, arousal, appetite, and energy homeostasis. It acts primarily through the OX2 receptor (orexin receptor type 2) to promote and maintain wakefulness and modulate feeding behavior. Research into orexin B is largely preclinical, but it has significant implications for understanding narcolepsy, sleep disorders, and metabolic regulation.

0 RCT · 0 human · 0 preclinical

sleep

PE-22-28

Animal

Novel TREK-1 inhibitor for mood and cognition

PE-22-28 is a synthetic peptide analog derived from the propeptide of neurotensin (also related to the TREK-1 channel inhibitor spadin), engineered to inhibit TREK-1 potassium channels in the brain. It has demonstrated rapid antidepressant-like effects in preclinical rodent models, often acting faster than conventional antidepressants. Research interest is growing due to its novel mechanism and potential to address treatment-resistant depression.

0 RCT · 0 human · 0 preclinical

mood

Semax

Animal

Nootropic ACTH analog for cognitive enhancement

Nootropic peptide for memory, focus & neuroprotection.

0 RCT · 0 human · 0 preclinical

cognition

Ziconotide (MVIIA ω-conotoxin)

Animal

Conotoxin analog for intractable pain

Conopeptide for severe intrathecal pain management.

0 RCT · 0 human · 0 preclinical

cognition

Adamax

Anecdotal

Nootropic peptide blend for cognition and mood

Adamax is a research peptide blend reported to combine nootropic and neuroprotective peptide components aimed at enhancing cognitive function, mood stability, and neural recovery. It is marketed primarily for its potential effects on dopaminergic and serotonergic signaling pathways. Evidence is largely limited to preclinical and anecdotal sources, with no published human clinical trials specific to the Adamax formulation.

0 RCT · 0 human · 0 preclinical

cognition

Davunetide (AL-108)

Anecdotal

NAPVSIPQ peptide for microtubule stabilization

Neuroprotective peptide for tauopathies (Alzheimer's, PSP).

0 RCT · 0 human · 0 preclinical

cognition

Dihexa

Anecdotal

Hepatocyte growth factor agonist for neurogenesis

Potent neurogenic peptide for cognitive repair.

0 RCT · 0 human · 0 preclinical

cognition

Humanin

Anecdotal

Mitochondrial peptide for brain protection

Mitochondrial-derived neuroprotective peptide.

0 RCT · 0 human · 0 preclinical

cognition

NAPVSIPQ (ADNP fragment)

Anecdotal

Active fragment of neuroprotective protein ADNP

Activity-dependent neuroprotective peptide fragment.

0 RCT · 0 human · 0 preclinical

cognition

Reference information for research purposes. Not medical advice, and not a recommendation to use any compound. Many entries describe substances that are not approved for human use.