The library
149 compounds. Every one graded.
Filter by research area or by how strong the evidence actually is. Profiles graded Animal or Anecdotal are not hidden they are labelled, which is more useful.
- Clinical
- 15
- Human-limited
- 61
- Animal
- 54
- Anecdotal
- 19
15 of 149 profiles
Focus & Memory
Oxytocin Acetate
ClinicalThe bonding hormone for trust and connection
Oxytocin Acetate is the acetate salt form of oxytocin, a naturally occurring nonapeptide hormone synthesized in the hypothalamus and released by the posterior pituitary gland. It plays central roles in social bonding, trust, stress reduction, sexual function, and uterine contraction. Research has expanded its potential applications to include anxiety reduction, prosocial behavior enhancement, and modulation of the hypothalamic-pituitary-adrenal (HPA) axis.
0 RCT · 0 human · 0 preclinical
mood
Selank
Human-limitedAnxiolytic peptide for calm focus and immune support
A synthetic heptapeptide derived from the immunomodulatory peptide tuftsin, developed in Russia for anxiolytic and nootropic effects without the sedation or dependence of benzodiazepines.
0 RCT · 0 human · 0 preclinical
cognition
Cerebrolysin
AnimalNeurotrophic peptide blend for cognitive repair
Neurotrophic peptide mix for brain repair & cognitive recovery.
0 RCT · 0 human · 0 preclinical
cognition
Cortagen
AnimalPineal-derived peptide for brain and immunity
Cortagen is a synthetic tetrapeptide (Ala-Glu-Asp-Pro) derived from the pineal gland and developed within the Russian peptide bioregulator program. It is primarily studied for its neuroprotective and immunomodulatory properties, with research suggesting it may support cortical function, slow age-related neurological decline, and modulate immune responses. Most of its evidence base comes from Russian preclinical and limited clinical studies conducted in the 1980s–2000s.
0 RCT · 0 human · 0 preclinical
cognition
Crystagen
AnimalOcular cytoprotection via crystallin chaperone mimicry
Crystagen is a synthetic peptide derived from the alpha-crystallin protein family, small heat-shock proteins (sHSPs) naturally abundant in the eye lens. It is investigated primarily for its cytoprotective and anti-apoptotic properties in ocular tissues, with emerging research suggesting neuroprotective and anti-inflammatory effects. Evidence is largely limited to animal and in vitro models, and no approved clinical use currently exists.
0 RCT · 0 human · 0 preclinical
eye
Dermorphin
AnimalUltra-potent frog-derived mu-opioid peptide
Dermorphin is a naturally occurring heptapeptide opioid first isolated from the skin secretions of South American phyllomedusa frogs. It binds with extraordinarily high selectivity and affinity to mu-opioid receptors, producing potent analgesic and sedative effects estimated to be 30–40 times more potent than morphine on a molar basis. Its unique structure incorporates a D-amino acid (D-Ala), which confers resistance to enzymatic degradation and prolongs its biological activity.
0 RCT · 0 human · 0 preclinical
mood
Orexin B
AnimalWakefulness neuropeptide driving arousal and cognition
Orexin B (also known as Hypocretin-2) is a neuropeptide produced in the lateral hypothalamus that plays a central role in regulating wakefulness, arousal, appetite, and energy homeostasis. It acts primarily through the OX2 receptor (orexin receptor type 2) to promote and maintain wakefulness and modulate feeding behavior. Research into orexin B is largely preclinical, but it has significant implications for understanding narcolepsy, sleep disorders, and metabolic regulation.
0 RCT · 0 human · 0 preclinical
sleep
PE-22-28
AnimalNovel TREK-1 inhibitor for mood and cognition
PE-22-28 is a synthetic peptide analog derived from the propeptide of neurotensin (also related to the TREK-1 channel inhibitor spadin), engineered to inhibit TREK-1 potassium channels in the brain. It has demonstrated rapid antidepressant-like effects in preclinical rodent models, often acting faster than conventional antidepressants. Research interest is growing due to its novel mechanism and potential to address treatment-resistant depression.
0 RCT · 0 human · 0 preclinical
mood
Semax
AnimalNootropic ACTH analog for cognitive enhancement
Nootropic peptide for memory, focus & neuroprotection.
0 RCT · 0 human · 0 preclinical
cognition
Ziconotide (MVIIA ω-conotoxin)
AnimalConotoxin analog for intractable pain
Conopeptide for severe intrathecal pain management.
0 RCT · 0 human · 0 preclinical
cognition
Adamax
AnecdotalNootropic peptide blend for cognition and mood
Adamax is a research peptide blend reported to combine nootropic and neuroprotective peptide components aimed at enhancing cognitive function, mood stability, and neural recovery. It is marketed primarily for its potential effects on dopaminergic and serotonergic signaling pathways. Evidence is largely limited to preclinical and anecdotal sources, with no published human clinical trials specific to the Adamax formulation.
0 RCT · 0 human · 0 preclinical
cognition
Davunetide (AL-108)
AnecdotalNAPVSIPQ peptide for microtubule stabilization
Neuroprotective peptide for tauopathies (Alzheimer's, PSP).
0 RCT · 0 human · 0 preclinical
cognition
Dihexa
AnecdotalHepatocyte growth factor agonist for neurogenesis
Potent neurogenic peptide for cognitive repair.
0 RCT · 0 human · 0 preclinical
cognition
Humanin
AnecdotalMitochondrial peptide for brain protection
Mitochondrial-derived neuroprotective peptide.
0 RCT · 0 human · 0 preclinical
cognition
NAPVSIPQ (ADNP fragment)
AnecdotalActive fragment of neuroprotective protein ADNP
Activity-dependent neuroprotective peptide fragment.
0 RCT · 0 human · 0 preclinical
cognition
Reference information for research purposes. Not medical advice, and not a recommendation to use any compound. Many entries describe substances that are not approved for human use.