Skip to content
AnimalNootropic ACTH analog for cognitive enhancement

Semax

Nootropic peptide for memory, focus & neuroprotection.

Overview

Modulates BDNF and neurotrophic factor expression in the hippocampus.

Proposed mechanism

ACTH analogue that stimulates working memory, increases hypoxia resistance, and improves cerebral circulation via BDNF modulation.

What the evidence supports

Most data comes from preclinical animal studies. Human clinical trial evidence is limited or absent.

Graded Animal

Evidence drawn from in vivo animal models or in vitro systems. Mechanistically informative; translation to humans is unproven.

Key citations

Representative primary sources, including results that did not favour the compound.

  1. [1]

    Semax in cognitive disorders

    · DOI:10.17116/jnevro201611651123-131 · 2016

  2. [2]

    ACTH analogues and cognition

    · DOI:10.1016/j.peptides.2016.11.004 · 2016

  3. [3]

    Semax in cognitive disorders (2016)

    · · 0

  4. [4]

    ACTH analogues and cognition (2016)

    · · 0

Citation records in this build are illustrative placeholders for the design.

Reference information for research purposes. Not medical advice, and not a recommendation to use any compound. Many entries describe substances that are not approved for human use.

Related profiles

Adamax

Anecdotal

Nootropic peptide blend for cognition and mood

Adamax is a research peptide blend reported to combine nootropic and neuroprotective peptide components aimed at enhancing cognitive function, mood stability, and neural recovery. It is marketed primarily for its potential effects on dopaminergic and serotonergic signaling pathways. Evidence is largely limited to preclinical and anecdotal sources, with no published human clinical trials specific to the Adamax formulation.

0 RCT · 0 human · 0 preclinical

cognition

Cerebrolysin

Animal

Neurotrophic peptide blend for cognitive repair

Neurotrophic peptide mix for brain repair & cognitive recovery.

0 RCT · 0 human · 0 preclinical

cognition

Cortagen

Animal

Pineal-derived peptide for brain and immunity

Cortagen is a synthetic tetrapeptide (Ala-Glu-Asp-Pro) derived from the pineal gland and developed within the Russian peptide bioregulator program. It is primarily studied for its neuroprotective and immunomodulatory properties, with research suggesting it may support cortical function, slow age-related neurological decline, and modulate immune responses. Most of its evidence base comes from Russian preclinical and limited clinical studies conducted in the 1980s–2000s.

0 RCT · 0 human · 0 preclinical

cognition