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AnecdotalNAPVSIPQ peptide for microtubule stabilization

Davunetide (AL-108)

Neuroprotective peptide for tauopathies (Alzheimer's, PSP).

Overview

Binds to tubulin and microtubule-associated proteins, reducing tau hyperphosphorylation and preserving axonal transport.

Proposed mechanism

Davunetide is a synthetic octapeptide (NAPVSIPQ) derived from activity-dependent neuroprotective protein (ADNP), that interacts with microtubule-associated proteins to stabilize tubulin and prevent tau aggregation.

What the evidence supports

Evidence rests primarily on self-reported experience. Controlled studies are lacking.

Graded Anecdotal

Case reports, clinician notes, and user-reported outcomes. Recorded for completeness and labelled plainly so it is never mistaken for data.

Key citations

Representative primary sources, including results that did not favour the compound.

  1. [1]

    Davunetide AL-108

    · DOI:10.1016/j.nbd.2008.12.004 · 2009

  2. [2]

    PSP trial davunetide

    · DOI:10.1016/S1474-4422(14)70038-6 · 2014

  3. [3]

    Davunetide AL-108 (2009)

    · · 0

  4. [4]

    PSP trial davunetide (2014)

    · · 0

Citation records in this build are illustrative placeholders for the design.

Reference information for research purposes. Not medical advice, and not a recommendation to use any compound. Many entries describe substances that are not approved for human use.

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