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AnimalConotoxin analog for intractable pain

Ziconotide (MVIIA ω-conotoxin)

Conopeptide for severe intrathecal pain management.

Overview

Binds with high affinity to N-type voltage-gated calcium channels (CaV2.2), inhibiting neurotransmitter release from primary afferent neurons.

Proposed mechanism

Ziconotide is a synthetic ω-conotoxin that selectively blocks N-type calcium channels in spinal cord, preventing pain neurotransmitter release (substance P, CGRP).

What the evidence supports

Most data comes from preclinical animal studies. Human clinical trial evidence is limited or absent.

Graded Animal

Evidence drawn from in vivo animal models or in vitro systems. Mechanistically informative; translation to humans is unproven.

Key citations

Representative primary sources, including results that did not favour the compound.

  1. [1]

    Ziconotide chronic pain

    · DOI:10.1016/S1474-4422(06)70455-3 · 2006

  2. [2]

    Conotoxins review

    · DOI:10.1111/j.1526-4637.2009.00672.x · 2009

  3. [3]

    Ziconotide chronic pain (2006)

    · · 0

  4. [4]

    Conotoxins review (2009)

    · · 0

Citation records in this build are illustrative placeholders for the design.

Reference information for research purposes. Not medical advice, and not a recommendation to use any compound. Many entries describe substances that are not approved for human use.

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