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Human-limitedAnxiolytic peptide for calm focus and immune support

Selank

Also indexed as TP-7, Selanck

A synthetic heptapeptide derived from the immunomodulatory peptide tuftsin, developed in Russia for anxiolytic and nootropic effects without the sedation or dependence of benzodiazepines.

Overview

Modulates GABA-A receptors to increase inhibitory action on neuronal excitability.

Proposed mechanism

Modulates GABA-A receptor expression, enhances brain-derived neurotrophic factor (BDNF) expression, and regulates enkephalin degradation, producing anxiolytic and cognitive-enhancing effects.

What the evidence supports

Human data exists but the trials are small, short-term, or not yet replicated.

Graded Human-limited

Human data that exists but is thin: open-label work, single-arm studies, small cohorts, or observational follow-up without randomisation.

Key citations

Representative primary sources, including results that did not favour the compound.

  1. [1]

    Selank in anxiety disorders

    · DOI:10.17116/jnevro201611651123-131 · 2016

  2. [2]

    Tuftsin analogs and anxiety

    · DOI:10.1007/s11055-015-0055-1 · 2015

  3. [3]

    Semenova et al. — Selank and anxiety in humans

    · · 0

  4. [4]

    Zozulya et al. — Selank as a stable tuftsin analogue

    · · 0

Citation records in this build are illustrative placeholders for the design.

Reference information for research purposes. Not medical advice, and not a recommendation to use any compound. Many entries describe substances that are not approved for human use.

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