149 compounds. Every one graded.

Anxiolytic peptide for calm focus and immune support

A synthetic heptapeptide derived from the immunomodulatory peptide tuftsin, developed in Russia for anxiolytic and nootropic effects without the sedation or dependence of benzodiazepines.

Ultra-potent frog-derived mu-opioid peptide

Dermorphin is a naturally occurring heptapeptide opioid first isolated from the skin secretions of South American phyllomedusa frogs. It binds with extraordinarily high selectivity and affinity to mu-opioid receptors, producing potent analgesic and sedative effects estimated to be 30–40 times more potent than morphine on a molar basis. Its unique structure incorporates a D-amino acid (D-Ala), which confers resistance to enzymatic degradation and prolongs its biological activity.

Potent frog-derived mu-opioid receptor agonist

Dermorphin is a naturally occurring heptapeptide opioid first isolated from the skin of South American Phyllomedusa frogs. It binds with extraordinarily high selectivity and potency to mu-opioid receptors, producing analgesic effects estimated to be 30–40 times more potent than morphine on a molar basis. Research has primarily been conducted in animal models, with extremely limited controlled human data available.

Delta sleep-inducing peptide for deep sleep

Natural peptide for deep sleep induction & stress reduction.

Pineal tetrapeptide for sleep and rhythm

A synthetic tetrapeptide derived from Epithalamin (a pineal gland extract) that has been studied for telomere elongation, circadian rhythm normalization, and lifespan extension in animal models.

Wakefulness neuropeptide driving arousal and cognition

Orexin B (also known as Hypocretin-2) is a neuropeptide produced in the lateral hypothalamus that plays a central role in regulating wakefulness, arousal, appetite, and energy homeostasis. It acts primarily through the OX2 receptor (orexin receptor type 2) to promote and maintain wakefulness and modulate feeding behavior. Research into orexin B is largely preclinical, but it has significant implications for understanding narcolepsy, sleep disorders, and metabolic regulation.

Novel TREK-1 inhibitor for mood and cognition

PE-22-28 is a synthetic peptide analog derived from the propeptide of neurotensin (also related to the TREK-1 channel inhibitor spadin), engineered to inhibit TREK-1 potassium channels in the brain. It has demonstrated rapid antidepressant-like effects in preclinical rodent models, often acting faster than conventional antidepressants. Research interest is growing due to its novel mechanism and potential to address treatment-resistant depression.

Pineal tripeptide for better sleep

Pineal peptide for circadian rhythm & sleep quality improvement.