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AnimalPineal tetrapeptide for sleep and rhythm

Epitalon

Also indexed as Epithalon, Epithalone, Ala-Glu-Asp-Gly

A synthetic tetrapeptide derived from Epithalamin (a pineal gland extract) that has been studied for telomere elongation, circadian rhythm normalization, and lifespan extension in animal models.

Overview

Interacts with pinealocytes to regulate melatonin production and circadian gene expression.

Proposed mechanism

Activates telomerase (hTERT), potentially extending telomere length in somatic cells. Also normalizes melatonin secretion by restoring pineal gland function, improving circadian rhythm and sleep architecture.

What the evidence supports

Most data comes from preclinical animal studies. Human clinical trial evidence is limited or absent.

Graded Animal

Evidence drawn from in vivo animal models or in vitro systems. Mechanistically informative; translation to humans is unproven.

Key citations

Representative primary sources, including results that did not favour the compound.

  1. [1]

    Epitalon effects on aging

    · DOI:10.1134/S0006297915020029 · 2015

  2. [2]

    Pineal peptides and sleep

    · DOI:10.1016/j.neulet.2008.06.003 · 2008

  3. [3]

    Khavinson et al. — Epithalon and telomerase activation

    · · 0

  4. [4]

    Anisimov et al. — Epitalon and lifespan in animals

    · · 0

  5. [5]

    Khavinson & Morozov — Epithalamin and aging

    · · 0

Citation records in this build are illustrative placeholders for the design.

Reference information for research purposes. Not medical advice, and not a recommendation to use any compound. Many entries describe substances that are not approved for human use.

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