Peptide profile
Epitalon
Pineal tetrapeptide for sleep and rhythm · also known as Epithalon, Epithalone, Ala-Glu-Asp-Gly
Compare Epitalon with other peptides →Summary
A synthetic tetrapeptide derived from Epithalamin (a pineal gland extract) that has been studied for telomere elongation, circadian rhythm normalization, and lifespan extension in animal models.
- Typical dose
- 5-10 mg/day for 10-20 day courses
- Half-life
- Estimated 1-2 hours
- Route
- Subcutaneous, Intramuscular
- Cycle length
- 10-20 days, 1-2 times per year
Mechanism
How it works
Activates telomerase (hTERT), potentially extending telomere length in somatic cells. Also normalizes melatonin secretion by restoring pineal gland function, improving circadian rhythm and sleep architecture.
Reported in research
Benefits
- Telomerase activation and telomere length support
- Restoration of melatonin production in aged subjects
- Improved circadian rhythm and sleep quality
- Antioxidant activity and reduction of lipid peroxidation
- Potential lifespan extension (demonstrated in animal models)
Context, not a prescription
Dosing
- Typical range
- 5-10 mg/day for 10-20 day courses (Subcutaneous, Intramuscular)
- Cycle length
- 10-20 days, 1-2 times per year
- Half-life
- Estimated 1-2 hours
Safety
Side effects & contraindications
Possible side effects
- Injection-site discomfort
- Vivid dreams or altered sleep patterns (early in protocol)
- Transient fatigue
Contraindications
- Active malignancy (telomerase activation is a theoretical concern in cancer cells)
- Pregnancy (insufficient data)
Research information, not medical advice. Always consult a licensed clinician before considering any peptide.
In depth
Full profile
What it does
You fall asleep faster, sleep deeper, and feel more awake in the day.
How it works
Epitalon is like a clock keeper for your cells. It helps reset your body's inside clock and helps you sleep better.
It works with cells in a small brain gland. It helps them make a sleep chemical and run your body clock.
What to expect
You sleep better in about 3-7 days.
- Days 3-5: You sleep better.
- Days 7-10: Your body clock works better.
- Days 10-20: You get the best sleep and body chemical effects.
Good to know
- Take the shot in the evening before bed
- Only use it for short times (10-20 days)
Staying safe
- A little soreness where the shot goes in
- Very clear dreams
- Feeling sleepy during the day for a short while
Avoid if you have:
- People who are pregnant or breastfeeding
- People who have cancer right now (just to be safe)
- People whose body fights itself (autoimmune problems)
Mechanism of action
Epitalon is a synthetic tetrapeptide that activates telomerase and influences melatonin synthesis via the pineal gland.
Interacts with pinealocytes to regulate melatonin production and circadian gene expression.
Pharmacodynamics
Sleep improvements within 3-7 days.
Improved sleep onset, deeper sleep, better daytime alertness.
Timeline
- Days 3-5: Improved sleep quality.
- Days 7-10: Better circadian rhythm.
- Days 10-20: Maximum sleep and endocrine effects.
Comparisons
- Epitalon — effectiveness Moderate, safety Good, cost $$, Easy to use
- Melatonin — effectiveness Moderate, safety Excellent, cost $, Very Easy to use
Adverse effects
Common:
- Mild injection site discomfort
- Vivid dreams
- Temporary daytime sleepiness
Rare:
- Headache
- Dizziness
Contraindications & risk mitigation
Contraindicated in:
- Pregnancy or breastfeeding
- Active cancer (theoretical risk)
- Autoimmune conditions
- Inject in evening before bed
- Short cycles only (10-20 days)
Qué hace
Te quedarás dormido más rápido, dormirás más profundo y te sentirás más despierto durante el día.
Cómo funciona
El Epitalon es como un guardián del reloj de tus células. Ayuda a reiniciar el reloj interno de tu cuerpo y te ayuda a dormir mejor.
Trabaja con las células de una pequeña glándula cerebral. Les ayuda a producir la sustancia para dormir y a regular el reloj de tu cuerpo.
Qué esperar
Dormirás mejor en unos 3-7 días.
- Días 3-5: Dormirás mejor.
- Días 7-10: Tu reloj interno funcionará mejor.
- Días 10-20: Obtendrás los mejores efectos en el sueño y en las sustancias químicas de tu cuerpo.
Bueno saber
- Aplicar la inyección por la noche antes de dormir
- Usarlo solo por períodos cortos (10-20 días)
Manteniéndose seguro
- Un poco de dolor donde se aplica la inyección
- Sueños muy vívidos
- Sensación de sueño durante el día por un corto tiempo
Evitar si tienes:
- Personas que están embarazadas o en período de lactancia
- Personas que tienen cáncer actualmente (solo por precaución)
- Personas con problemas autoinmunes (cuando el cuerpo se ataca a sí mismo)
Mecanismo de acción
El Epitalon es un tetrapéptido sintético que activa la telomerasa e influye en la síntesis de melatonina a través de la glándula pineal.
Interactúa con los pinealocitos para regular la producción de melatonina y la expresión génica circadiana.
Farmacodinamia
Mejoras en el sueño en 3-7 días.
Inicio del sueño mejorado, sueño más profundo, mayor alerta durante el día.
Cronología
- Días 3-5: Mejora de la calidad del sueño.
- Días 7-10: Mejor ritmo circadiano.
- Días 10-20: Efectos máximos en el sueño y el sistema endocrino.
Comparaciones
- Epitalon — efectividad Moderada, seguridad Buena, costo $$, Fácil de usar
- Melatonina — efectividad Moderada, seguridad Excelente, costo $, Muy fácil de usar
Efectos adversos
Comunes:
- Molestias leves en el sitio de inyección
- Sueños vívidos
- Somnolencia diurna temporal
Raros:
- Dolor de cabeza
- Mareos
Contraindicaciones y mitigación de riesgos
Contraindicado en:
- Embarazo o lactancia
- Cáncer activo (riesgo teórico)
- Enfermedades autoinmunes
- Inyectar por la noche antes de dormir
- Solo ciclos cortos (10-20 días)
Reference data
Specifications
- Molecular formula
- C14H22N4O9
- Molecular weight
- 390.3 g/mol
- Half-life
- Estimated 1-2 hours
- Route
- Subcutaneous, Intramuscular
- Cycle length
- 10-20 days, 1-2 times per year
- Storage
- Lyophilized: refrigerate for long-term storage. Reconstituted: refrigerate at 2-8 C, use within 30 days.
- Legal status
- Research chemical; not approved by FDA, EMA, or major regulatory bodies for human therapeutic use.
FAQ
Common questions
Is epitalon safe for long-term use?
Short cycles (10-20 days) every 3-6 months are typical; long-term safety data is limited.
Does epitalon help with jet lag?
Yes, by resetting circadian rhythm, it may help with jet lag recovery.
What is the evidence level?
This compound is classified as Animal data. Most data comes from preclinical animal studies. Human clinical trial evidence is limited or absent.
Research
Research & sources
Current evidence for Epitalon is rated as Animal data. Research is based primarily on animal models.
- 1. Epitalon effects on aging (2015) — DOI:10.1134/S0006297915020029
- 2. Pineal peptides and sleep (2008) — DOI:10.1016/j.neulet.2008.06.003
- 3. Khavinson et al. — Epithalon and telomerase activation
- 4. Anisimov et al. — Epitalon and lifespan in animals
- 5. Khavinson & Morozov — Epithalamin and aging
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