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AnimalAcetyl tetrapeptide-3 for AGE prevention

Acetyl Tetrapeptide-3 (Darnosine)

Advanced AGE-breaker for deep anti-wrinkle action.

Overview

Neutralizes methylglyoxal and other advanced glycation intermediates, protecting extracellular matrix proteins.

Proposed mechanism

Acetyl tetrapeptide-3 is a carnosine derivative that scavenges reactive carbonyl species and prevents cross-linking of collagen and elastin by sugars.

What the evidence supports

Most data comes from preclinical animal studies. Human clinical trial evidence is limited or absent.

Graded Animal

Evidence drawn from in vivo animal models or in vitro systems. Mechanistically informative; translation to humans is unproven.

Key citations

Representative primary sources, including results that did not favour the compound.

  1. [1]

    Carnosine derivatives in anti-glycation

    · DOI:10.1111/j.1473-2165.2008.00399.x · 2008

  2. [2]

    Tetrapeptide-30 (Darnosine)

    · DOI:10.1111/jocd.12591 · 2018

  3. [3]

    Carnosine derivatives in anti-glycation (2008)

    · · 0

  4. [4]

    Tetrapeptide-30 (Darnosine) (2018)

    · · 0

Citation records in this build are illustrative placeholders for the design.

Reference information for research purposes. Not medical advice, and not a recommendation to use any compound. Many entries describe substances that are not approved for human use.

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