DSIP (Delta Sleep-Inducing Peptide)

Ultra-potent frog-derived mu-opioid peptide

Dermorphin is a naturally occurring heptapeptide opioid first isolated from the skin secretions of South American phyllomedusa frogs. It binds with extraordinarily high selectivity and affinity to mu-opioid receptors, producing potent analgesic and sedative effects estimated to be 30–40 times more potent than morphine on a molar basis. Its unique structure incorporates a D-amino acid (D-Ala), which confers resistance to enzymatic degradation and prolongs its biological activity.

Potent frog-derived mu-opioid receptor agonist

Dermorphin is a naturally occurring heptapeptide opioid first isolated from the skin of South American Phyllomedusa frogs. It binds with extraordinarily high selectivity and potency to mu-opioid receptors, producing analgesic effects estimated to be 30–40 times more potent than morphine on a molar basis. Research has primarily been conducted in animal models, with extremely limited controlled human data available.

Pineal tetrapeptide for sleep and rhythm

A synthetic tetrapeptide derived from Epithalamin (a pineal gland extract) that has been studied for telomere elongation, circadian rhythm normalization, and lifespan extension in animal models.