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Human-limitedLong-acting GLP-1 receptor agonist

Dulaglutide

Weekly GLP-1 agonist for diabetes & weight management.

Overview

Binds and activates GLP-1 receptors on pancreatic beta cells, neurons, and gut; slows gastric emptying and reduces glucagon secretion.

Proposed mechanism

Dulaglutide is a GLP-1 receptor agonist fused to an Fc fragment of human IgG4 for extended half-life (~5 days), activating GLP-1 receptors throughout body.

What the evidence supports

Human data exists but the trials are small, short-term, or not yet replicated.

Graded Human-limited

Human data that exists but is thin: open-label work, single-arm studies, small cohorts, or observational follow-up without randomisation.

Key citations

Representative primary sources, including results that did not favour the compound.

  1. [1]

    AWARD trial dulaglutide

    · DOI:10.2337/dc16-0057 · 2016

  2. [2]

    REWIND cardiovascular

    · DOI:10.1016/S0140-6736(19)31149-3 · 2019

  3. [3]

    AWARD trial dulaglutide (2016)

    · · 0

  4. [4]

    REWIND cardiovascular (2019)

    · · 0

Citation records in this build are illustrative placeholders for the design.

Reference information for research purposes. Not medical advice, and not a recommendation to use any compound. Many entries describe substances that are not approved for human use.

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