Overview
Interacts with fibroblasts and stem cells to deliver copper to enzymes needed for repair.
Proposed mechanism
Binds copper(II) with high affinity and acts as a chaperone for copper-dependent enzymes. Activates genes associated with tissue repair, antioxidant defense, and collagen synthesis while downregulating inflammatory and tumor-promoting pathways.
What the evidence supports
Human data exists but the trials are small, short-term, or not yet replicated.
Graded Human-limited
Human data that exists but is thin: open-label work, single-arm studies, small cohorts, or observational follow-up without randomisation.
Key citations
Representative primary sources, including results that did not favour the compound.
- [1]
GHK Peptide as a Natural Modulator
· DOI:10.3390/ijms19071987 · 2018
- [2]
The human tri-peptide GHK-Cu
· DOI:10.1111/jocd.12166 · 2015
- [3]
Pickart et al. — GHK-Cu and human gene expression
· · 0
- [4]
Pickart & Margolina — Regenerative and protective actions of copper peptide GHK-Cu
· · 0
Citation records in this build are illustrative placeholders for the design.
Reference information for research purposes. Not medical advice, and not a recommendation to use any compound. Many entries describe substances that are not approved for human use.