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AnimalEndogenous GLP-1 for meal-time satiety

GLP-1 (7-36) Amide

Native GLP-1 peptide for acute appetite control.

Overview

Activates GLP-1 receptors on pancreatic beta cells (insulin secretion), gastric smooth muscle (delayed emptying), and hypothalamic satiety centers.

Proposed mechanism

GLP-1 (7-36) amide is the biologically active form of endogenous glucagon-like peptide-1 with a half-life of less than 2 minutes, rapidly metabolized by DPP-4 enzymes.

What the evidence supports

Most data comes from preclinical animal studies. Human clinical trial evidence is limited or absent.

Graded Animal

Evidence drawn from in vivo animal models or in vitro systems. Mechanistically informative; translation to humans is unproven.

Key citations

Representative primary sources, including results that did not favour the compound.

  1. [1]

    GLP-1 physiology

    · DOI:10.1152/physrev.00034.2011 · 2012

  2. [2]

    Short-acting GLP-1 agonists

    · DOI:10.2337/dc19-0045 · 2019

  3. [3]

    GLP-1 physiology (2012)

    · · 0

  4. [4]

    Short-acting GLP-1 agonists (2019)

    · · 0

Citation records in this build are illustrative placeholders for the design.

Reference information for research purposes. Not medical advice, and not a recommendation to use any compound. Many entries describe substances that are not approved for human use.

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