Overview
Binds GHS-R1a receptors, activates phospholipase C and increases intracellular calcium.
Proposed mechanism
Synthetic hexapeptide GHS that binds to ghrelin receptors (GHS-R1a) in pituitary and hypothalamus, stimulating potent GH pulses.
What the evidence supports
Human data exists but the trials are small, short-term, or not yet replicated.
Graded Human-limited
Human data that exists but is thin: open-label work, single-arm studies, small cohorts, or observational follow-up without randomisation.
Key citations
Representative primary sources, including results that did not favour the compound.
- [1]
Hexarelin cardioprotection
· DOI:10.1152/ajpheart.2000.278.3.H842 · 2000
- [2]
GHS and GH release
· DOI:10.1210/er.2009-0006 · 2009
- [3]
Hexarelin cardioprotection (2000)
· · 0
- [4]
GHS and GH release (2009)
· · 0
Citation records in this build are illustrative placeholders for the design.
Reference information for research purposes. Not medical advice, and not a recommendation to use any compound. Many entries describe substances that are not approved for human use.