Overview
Binds to melanocortin receptors (MC1R, MC3R) on immune cells in gut-associated lymphoid tissue, reducing NF-κB activation.
Proposed mechanism
Cyclo-KPV is a chemically cyclized form of KPV that resists enzymatic degradation in the GI tract, increasing bioavailability for systemic anti-inflammatory effects.
What the evidence supports
Evidence rests primarily on self-reported experience. Controlled studies are lacking.
Graded Anecdotal
Case reports, clinician notes, and user-reported outcomes. Recorded for completeness and labelled plainly so it is never mistaken for data.
Key citations
Representative primary sources, including results that did not favour the compound.
- [1]
Cyclized KPV in IBD
· DOI:10.1016/j.ejmech.2018.07.056 · 2018
- [2]
Cyclic peptides gut stability
· DOI:10.1021/acs.chemrev.8b00804 · 2019
- [3]
Cyclized KPV in IBD (2018)
· · 0
- [4]
Cyclic peptides gut stability (2019)
· · 0
Citation records in this build are illustrative placeholders for the design.
Reference information for research purposes. Not medical advice, and not a recommendation to use any compound. Many entries describe substances that are not approved for human use.