Overview
Increases plasma ornithine, arginine, glutamate, and glutamine levels; stimulates mTOR pathway and reduces protein breakdown.
Proposed mechanism
OKG is a salt of ornithine and α-ketoglutarate that stimulates insulin and growth hormone secretion while providing glutamate and arginine precursors.
What the evidence supports
Human data exists but the trials are small, short-term, or not yet replicated.
Graded Human-limited
Human data that exists but is thin: open-label work, single-arm studies, small cohorts, or observational follow-up without randomisation.
Key citations
Representative primary sources, including results that did not favour the compound.
- [1]
OKG in catabolic states
· DOI:10.1097/00005792-199201000-00004 · 1992
- [2]
Ornithine α-ketoglutarate
· DOI:10.1097/00075197-200005000-00002 · 2000
- [3]
OKG in catabolic states (1992)
· · 0
- [4]
Ornithine α-ketoglutarate (2000)
· · 0
Citation records in this build are illustrative placeholders for the design.
Reference information for research purposes. Not medical advice, and not a recommendation to use any compound. Many entries describe substances that are not approved for human use.