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Human-limitedFDA-approved GHRH analog for fat reduction

Tesamorelin

GHRH analog for visceral fat reduction & GH elevation.

Overview

GHRH receptor agonist, increases GH secretion, which then acts on fat cells to release free fatty acids.

Proposed mechanism

Synthetic GHRH analogue that binds GHRH receptors on pituitary somatotrophs to increase GH pulse amplitude and IGF-1 production.

What the evidence supports

Human data exists but the trials are small, short-term, or not yet replicated.

Graded Human-limited

Human data that exists but is thin: open-label work, single-arm studies, small cohorts, or observational follow-up without randomisation.

Key citations

Representative primary sources, including results that did not favour the compound.

  1. [1]

    Tesamorelin for visceral fat

    · DOI:10.1001/jama.2013.281204 · 2013

  2. [2]

    FDA approval Egrifta

    · DOI:10.1038/nrd3131 · 2010

  3. [3]

    Tesamorelin for visceral fat (2013)

    · · 0

  4. [4]

    FDA approval Egrifta (2010)

    · · 0

Citation records in this build are illustrative placeholders for the design.

Reference information for research purposes. Not medical advice, and not a recommendation to use any compound. Many entries describe substances that are not approved for human use.

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