149 compounds. Every one graded.

Full-length adrenal hormone with broad receptor activity

ACTH 1-39 is the full-length, biologically active form of adrenocorticotropic hormone, a 39-amino acid peptide naturally secreted by the anterior pituitary gland. It primarily stimulates the adrenal cortex to produce cortisol, aldosterone, and adrenal androgens. Beyond adrenal signaling, ACTH 1-39 exerts direct effects on the brain, immune system, and peripheral tissues via melanocortin receptors.

The bonding hormone for trust and connection

Oxytocin Acetate is the acetate salt form of oxytocin, a naturally occurring nonapeptide hormone synthesized in the hypothalamus and released by the posterior pituitary gland. It plays central roles in social bonding, trust, stress reduction, sexual function, and uterine contraction. Research has expanded its potential applications to include anxiety reduction, prosocial behavior enhancement, and modulation of the hypothalamic-pituitary-adrenal (HPA) axis.

Central nervous system sexual desire activator

PT-141 (Bremelanotide) is a synthetic melanocortin receptor agonist originally derived from the tanning peptide Melanotan II. It is used to treat hypoactive sexual desire disorder (HSDD) and erectile dysfunction by acting centrally on the brain rather than peripherally on blood vessels. Unlike PDE5 inhibitors, PT-141 works through the central nervous system to increase sexual desire and arousal in both men and women.

Tissue-protective peptide for nerve repair and inflammation

ARA290, also known as Cibinetide, is a synthetic 11-amino acid peptide derived from the helix B surface peptide of erythropoietin (EPO) that selectively activates the innate repair receptor (IRR) without stimulating erythropoiesis. It is designed to harness the tissue-protective and anti-inflammatory properties of EPO while avoiding its hematopoietic side effects. Clinically, it has been investigated for neuropathic pain, small fiber neuropathy, and inflammatory conditions such as sarcoidosis.

Endogenous HPG axis activator for sexual health

Kisspeptin-10 is the biologically active C-terminal decapeptide fragment of the larger kisspeptin precursor protein, encoded by the KISS1 gene. It acts as a potent endogenous activator of the hypothalamic-pituitary-gonadal (HPG) axis, stimulating the release of gonadotropin-releasing hormone (GnRH) and downstream luteinizing hormone (LH) and follicle-stimulating hormone (FSH). It is investigated for applications in reproductive endocrinology, sexual function, and mood regulation.

Ultra-potent frog-derived mu-opioid peptide

Dermorphin is a naturally occurring heptapeptide opioid first isolated from the skin secretions of South American phyllomedusa frogs. It binds with extraordinarily high selectivity and affinity to mu-opioid receptors, producing potent analgesic and sedative effects estimated to be 30–40 times more potent than morphine on a molar basis. Its unique structure incorporates a D-amino acid (D-Ala), which confers resistance to enzymatic degradation and prolongs its biological activity.

Potent frog-derived mu-opioid receptor agonist

Dermorphin is a naturally occurring heptapeptide opioid first isolated from the skin of South American Phyllomedusa frogs. It binds with extraordinarily high selectivity and potency to mu-opioid receptors, producing analgesic effects estimated to be 30–40 times more potent than morphine on a molar basis. Research has primarily been conducted in animal models, with extremely limited controlled human data available.

Wakefulness neuropeptide driving arousal and cognition

Orexin B (also known as Hypocretin-2) is a neuropeptide produced in the lateral hypothalamus that plays a central role in regulating wakefulness, arousal, appetite, and energy homeostasis. It acts primarily through the OX2 receptor (orexin receptor type 2) to promote and maintain wakefulness and modulate feeding behavior. Research into orexin B is largely preclinical, but it has significant implications for understanding narcolepsy, sleep disorders, and metabolic regulation.

Novel TREK-1 inhibitor for mood and cognition

PE-22-28 is a synthetic peptide analog derived from the propeptide of neurotensin (also related to the TREK-1 channel inhibitor spadin), engineered to inhibit TREK-1 potassium channels in the brain. It has demonstrated rapid antidepressant-like effects in preclinical rodent models, often acting faster than conventional antidepressants. Research interest is growing due to its novel mechanism and potential to address treatment-resistant depression.

Nootropic peptide blend for cognition and mood

Adamax is a research peptide blend reported to combine nootropic and neuroprotective peptide components aimed at enhancing cognitive function, mood stability, and neural recovery. It is marketed primarily for its potential effects on dopaminergic and serotonergic signaling pathways. Evidence is largely limited to preclinical and anecdotal sources, with no published human clinical trials specific to the Adamax formulation.