Peptide profile
Acetyl Tetrapeptide-5 (Eyeseryl)
Acetyl tetrapeptide-5 for eye area
Compare Acetyl Tetrapeptide-5 (Eyeseryl) with other peptides →Summary
A skin helper that makes puffy eyes look better.
- Typical dose
- 1-3% concentration 2x daily
- Route
- Topical
- Cycle length
- Ongoing
- Evidence
- Limited human data
Mechanism
How it works
Eyeseryl acts like a drain unclogger for your under-eye area — it encourages lymph flow to flush out trapped fluid causing puffiness.
Acetyl tetrapeptide-5 is an analog of thymopoietin, which activates the lymphatic drainage system and reduces fluid accumulation.
Reported in research
Benefits
- Makes puffy bags under your eyes look smaller
- Helps fade dark circles
- Helps blood flow better in tiny veins
- Calms the gentle skin around your eyes
Context, not a prescription
Dosing
- Typical range
- 1-3% concentration 2x daily (Topical)
- Cycle length
- Ongoing
Safety
Side effects & contraindications
Possible side effects
- Minimal; very well tolerated
- Mild transient stinging
Contraindications
- Known peptide sensitivity
Research information, not medical advice. Always consult a licensed clinician before considering any peptide.
In depth
Full profile
What it does
Less puffy eyes, lighter dark circles, and firmer skin around your eyes.
How it works
Eyeseryl works like a drain cleaner for under your eyes. It helps push out trapped fluid that makes eyes look puffy.
It connects to tiny drain pipes near your eyes. This helps move fluid away and calms puffy, swollen skin.
What to expect
You can see it working in 2-4 weeks.
- Weeks 1-2: Less puffy eyes in the morning.
- Weeks 3-4: Dark circles look lighter.
- Weeks 6-8: Skin under your eyes feels firmer.
Good to know
- Test a tiny bit near your eye first
Staying safe
- Almost none; very easy on the skin
Avoid if you have:
- People whose skin reacts badly to peptides
Mechanism of action
Acetyl tetrapeptide-5 is an analog of thymopoietin, which activates the lymphatic drainage system and reduces fluid accumulation.
Binds to lymphatic vessel receptors, promoting drainage and reducing inflammation in periorbital tissue.
Pharmacodynamics
Visible improvement at 2-4 weeks.
Less under-eye puffiness, reduced dark circles, firmer eye contour.
Timeline
- Weeks 1-2: Reduced morning puffiness.
- Weeks 3-4: Less visible dark circles.
- Weeks 6-8: Firmer under-eye area.
Comparisons
- Eyeseryl — effectiveness Moderate, safety Excellent, cost $$, Very Easy to use
- Caffeine — effectiveness Low, safety Excellent, cost $, Very Easy to use
Adverse effects
Common:
- Minimal; very well tolerated
Rare:
- Mild transient stinging
Contraindications & risk mitigation
Contraindicated in:
- Known peptide sensitivity
- Patch test near eye area
Qué hace
Menos ojos hinchados, ojeras más claras y piel más firme alrededor de los ojos.
Cómo funciona
Eyeseryl funciona como un desatascador debajo de los ojos. Ayuda a expulsar el líquido atrapado que hace que los ojos se vean hinchados.
Se conecta a pequeños conductos de drenaje cerca de los ojos. Esto ayuda a mover el líquido y calma la piel hinchada e inflamada.
Qué esperar
Puedes ver resultados en 2-4 semanas.
- Semanas 1-2: Menos hinchazón en los ojos por la mañana.
- Semanas 3-4: Las ojeras se ven más claras.
- Semanas 6-8: La piel debajo de los ojos se siente más firme.
Bueno saber
- Prueba una pequeña cantidad cerca del ojo primero
Manteniéndose seguro
- Casi ninguno; muy suave con la piel
Evitar si tienes:
- Personas cuya piel reacciona mal a los péptidos
Mecanismo de acción
El acetil tetrapéptido-5 es un análogo de la timopoietina, que activa el sistema de drenaje linfático y reduce la acumulación de líquidos.
Se une a los receptores de los vasos linfáticos, promoviendo el drenaje y reduciendo la inflamación en el tejido periorbital.
Farmacodinamia
Mejora visible a las 2-4 semanas.
Menos hinchazón debajo de los ojos, reducción de ojeras, contorno ocular más firme.
Cronología
- Semanas 1-2: Reducción de la hinchazón matutina.
- Semanas 3-4: Ojeras menos visibles.
- Semanas 6-8: Zona debajo de los ojos más firme.
Comparaciones
- Eyeseryl — efectividad Moderada, seguridad Excelente, costo $$, Muy fácil de usar
- Cafeína — efectividad Baja, seguridad Excelente, costo $, Muy fácil de usar
Efectos adversos
Comunes:
- Mínimos; muy bien tolerado
Raros:
- Ligero ardor transitorio
Contraindicaciones y mitigación de riesgos
Contraindicado en:
- Sensibilidad conocida a péptidos
- Realizar prueba de parche cerca de la zona ocular
Reference data
Specifications
- Route
- Topical
- Cycle length
- Ongoing
FAQ
Common questions
Does it work for genetic under-eye bags?
Partial improvement; severe genetic bags may require cosmetic procedures.
Can it be used with retinol?
Yes, but use retinol around eyes with caution as it can be irritating.
What is the evidence level?
This compound is classified as Limited human data. Some human data exists but trials are small, short-term, or not yet replicated.
Research
Research & sources
Current evidence for Acetyl Tetrapeptide-5 (Eyeseryl) is rated as Limited human data. Limited human data is available.
- 1. Eyeseryl clinical study (2008) — DOI:10.1111/j.1468-2494.2008.00486.x
- 2. Peptides for periorbital area (2019) — DOI:10.1111/jocd.12949
- 3. Eyeseryl clinical study (2008)
- 4. Peptides for periorbital area (2019)