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Human-limitedTopical copper peptide for wound repair

GHK-Cu (Topical)

Copper tripeptide for accelerated wound healing & scar reduction.

Overview

Binds to copper-dependent enzymes (lysyl oxidase) and modulates over 4,000 genes involved in repair.

Proposed mechanism

GHK-Cu delivers copper to wound healing enzymes, activates fibroblasts, reduces inflammation, and promotes organized collagen deposition.

What the evidence supports

Human data exists but the trials are small, short-term, or not yet replicated.

Graded Human-limited

Human data that exists but is thin: open-label work, single-arm studies, small cohorts, or observational follow-up without randomisation.

Key citations

Representative primary sources, including results that did not favour the compound.

  1. [1]

    GHK-Cu in wound healing

    · DOI:10.1111/jocd.12693 · 2018

  2. [2]

    Copper peptides in repair

    · DOI:10.3390/ijms19071987 · 2018

  3. [3]

    GHK-Cu in wound healing (2018)

    · · 0

  4. [4]

    Copper peptides in repair (2018)

    · · 0

Citation records in this build are illustrative placeholders for the design.

Reference information for research purposes. Not medical advice, and not a recommendation to use any compound. Many entries describe substances that are not approved for human use.

Related profiles

AHK-Cu

Human-limited

Copper peptide for skin regeneration and repair

AHK-Cu is a copper-binding tripeptide (Ala-His-Lys) complexed with copper(II) ions, closely related to the well-studied GHK-Cu peptide. It stimulates collagen and glycosaminoglycan synthesis in skin fibroblasts while exerting antioxidant and anti-inflammatory activity. Primarily researched in the context of skin regeneration, wound healing, and hair follicle stimulation.

0 RCT · 0 human · 0 preclinical

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B7-33

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B7-33 is a single-chain peptide analog of human relaxin-2, engineered to selectively activate the RXFP1 receptor without triggering the cAMP signaling pathway. It demonstrates potent anti-fibrotic, vasodilatory, and cardioprotective effects in preclinical models. Research primarily focuses on its potential in heart failure, pulmonary arterial hypertension, and organ fibrosis.

0 RCT · 0 human · 0 preclinical

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BPC-157

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Systemic healing for wounds, tendons, and gut

A synthetic pentadecapeptide derived from a protein in gastric juice, studied for tissue repair, gut protection, and musculoskeletal healing.

0 RCT · 0 human · 0 preclinical

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