Peptide profile
Gonadorelin
Gonadotropin-releasing hormone agonist
Compare Gonadorelin with other peptides →Summary
GnRH analog for fertility and hormonal assessment.
- Typical dose
- 100-500mcg (single dose) or variable (pump) Single test or pulsatile every 60-90 minutes
- Route
- Subcutaneous, Intramuscular
- Cycle length
- Short-term
- Evidence
- Limited human data
Mechanism
How it works
Gonadorelin acts like a starter pistol for your reproductive system — it tells your pituitary gland to release LH and FSH, which then tell your gonads to make hormones and gametes.
Gonadorelin is synthetic luteinizing hormone-releasing hormone (LHRH) stimulating pituitary release of LH and FSH, used both diagnostically and therapeutically.
Reported in research
Benefits
- Increases LH and FSH (diagnostic test)
- Treats hypogonadotropic hypogonadism
- Induces ovulation in women
- Used in pulsatile pump for fertility
Context, not a prescription
Dosing
- Typical range
- 100-500mcg (single dose) or variable (pump) Single test or pulsatile every 60-90 minutes (Subcutaneous, Intramuscular)
- Cycle length
- Short-term
Safety
Side effects & contraindications
Possible side effects
- Injection site pain
- Nausea
- Headache
- Ovarian hyperstimulation (women)
- Allergic reaction
Contraindications
- Pregnancy (may cause miscarriage)
- Sex hormone-sensitive cancer
- Uncontrolled thyroid or adrenal disease
Research information, not medical advice. Always consult a licensed clinician before considering any peptide.
In depth
Full profile
What it does
Increased LH/FSH → increased testosterone in men, ovulation induction in women.
How it works
Gonadorelin acts like a starter pistol for your reproductive system — it tells your pituitary gland to release LH and FSH, which then tell your gonads to make hormones and gametes.
Binds to GnRH receptors on pituitary gonadotroph cells, triggering calcium flux and hormone synthesis/secretion.
What to expect
LH release within 20-30 minutes; pulsatile over days.
- Within 30 minutes: Peak LH release (single dose).
- Pulsatile days: Progressive gonadal stimulation.
- Weeks (pump): Fertility restoration.
Good to know
- Use only under medical supervision
- Monitor for signs of ovarian hyperstimulation
Staying safe
- Injection site pain
- Nausea
- Headache
Avoid if you have:
- Pregnancy (may cause miscarriage)
- Sex hormone-sensitive cancer
- Uncontrolled thyroid or adrenal disease
Mechanism of action
Gonadorelin is synthetic luteinizing hormone-releasing hormone (LHRH) stimulating pituitary release of LH and FSH, used both diagnostically and therapeutically.
Binds to GnRH receptors on pituitary gonadotroph cells, triggering calcium flux and hormone synthesis/secretion.
Pharmacodynamics
LH release within 20-30 minutes; pulsatile over days.
Increased LH/FSH → increased testosterone in men, ovulation induction in women.
Timeline
- Within 30 minutes: Peak LH release (single dose).
- Pulsatile days: Progressive gonadal stimulation.
- Weeks (pump): Fertility restoration.
Comparisons
- Gonadorelin — effectiveness High, safety Good, cost $$, Medium to use
- HCG — effectiveness High, safety Good, cost $$, Easy to use
Adverse effects
Common:
- Injection site pain
- Nausea
- Headache
Rare:
- Ovarian hyperstimulation (women)
- Allergic reaction
Contraindications & risk mitigation
Contraindicated in:
- Pregnancy (may cause miscarriage)
- Sex hormone-sensitive cancer
- Uncontrolled thyroid or adrenal disease
- Use only under medical supervision
- Monitor for signs of ovarian hyperstimulation
Qué hace
Aumento de LH/FSH → mayor testosterona en hombres, inducción de ovulación en mujeres.
Cómo funciona
La gonadorelina actúa como una pistola de salida para tu sistema reproductivo: le indica a tu glándula pituitaria que libere LH y FSH, las cuales luego le dicen a tus gónadas que produzcan hormonas y gametos.
Se une a los receptores de GnRH en las células gonadotrofas de la pituitaria, desencadenando un flujo de calcio y la síntesis/secretión de hormonas.
Qué esperar
Liberación de LH en 20-30 minutos; pulsátil a lo largo de días.
- En menos de 30 minutos: Liberación máxima de LH (dosis única).
- Días pulsátiles: Estimulación gonadal progresiva.
- Semanas (bomba): Restauración de la fertilidad.
Bueno saber
- Usar solo bajo supervisión médica
- Vigilar signos de hiperestimulación ovárica
Manteniéndose seguro
- Dolor en el sitio de inyección
- Náuseas
- Dolor de cabeza
Evitar si tienes:
- Embarazo (puede causar aborto espontáneo)
- Cáncer sensible a hormonas sexuales
- Enfermedad tiroidea o suprarrenal no controlada
Mecanismo de acción
La gonadorelina es una hormona liberadora de hormona luteinizante (LHRH) sintética que estimula la liberación pituitaria de LH y FSH, utilizada tanto con fines diagnósticos como terapéuticos.
Se une a los receptores de GnRH en las células gonadotrofas de la pituitaria, desencadenando un flujo de calcio y la síntesis/secretión de hormonas.
Farmacodinamia
Liberación de LH en 20-30 minutos; pulsátil a lo largo de días.
Aumento de LH/FSH → mayor testosterona en hombres, inducción de ovulación en mujeres.
Cronología
- En menos de 30 minutos: Liberación máxima de LH (dosis única).
- Días pulsátiles: Estimulación gonadal progresiva.
- Semanas (bomba): Restauración de la fertilidad.
Comparaciones
- Gonadorelin — efectividad Alta, seguridad Buena, costo $$, Media de usar
- HCG — efectividad Alta, seguridad Buena, costo $$, Fácil de usar
Efectos adversos
Comunes:
- Dolor en el sitio de inyección
- Náuseas
- Dolor de cabeza
Raros:
- Hiperestimulación ovárica (mujeres)
- Reacción alérgica
Contraindicaciones y mitigación de riesgos
Contraindicado en:
- Embarazo (puede causar aborto espontáneo)
- Cáncer sensible a hormonas sexuales
- Enfermedad tiroidea o suprarrenal no controlada
- Usar solo bajo supervisión médica
- Vigilar signos de hiperestimulación ovárica
Reference data
Specifications
- Route
- Subcutaneous, Intramuscular
- Cycle length
- Short-term
FAQ
Common questions
Is gonadorelin used for low testosterone?
Yes, in hypothalamic origin (pulsatile). Not effective if pituitary or testicular issue.
What is the pulsatile pump?
A portable pump that delivers minute doses every 60-90 minutes to mimic natural GnRH pulses.
What is the evidence level?
This compound is classified as Limited human data. Some human data exists but trials are small, short-term, or not yet replicated.
Research
Research & sources
Current evidence for Gonadorelin is rated as Limited human data. Limited human data is available.
- 1. Gonadorelin in hypogonadism (2003) — DOI:10.1210/jc.2002-021230
- 2. GnRH therapy (2014) — DOI:10.1210/er.2014-1018
- 3. Gonadorelin in hypogonadism (2003)
- 4. GnRH therapy (2014)