Skip to content
Human-limitedGonadotropin-releasing hormone agonist

Gonadorelin

GnRH analog for fertility and hormonal assessment.

Overview

Binds to GnRH receptors on pituitary gonadotroph cells, triggering calcium flux and hormone synthesis/secretion.

Proposed mechanism

Gonadorelin is synthetic luteinizing hormone-releasing hormone (LHRH) stimulating pituitary release of LH and FSH, used both diagnostically and therapeutically.

What the evidence supports

Human data exists but the trials are small, short-term, or not yet replicated.

Graded Human-limited

Human data that exists but is thin: open-label work, single-arm studies, small cohorts, or observational follow-up without randomisation.

Key citations

Representative primary sources, including results that did not favour the compound.

  1. [1]

    Gonadorelin in hypogonadism

    · DOI:10.1210/jc.2002-021230 · 2003

  2. [2]

    GnRH therapy

    · DOI:10.1210/er.2014-1018 · 2014

  3. [3]

    Gonadorelin in hypogonadism (2003)

    · · 0

  4. [4]

    GnRH therapy (2014)

    · · 0

Citation records in this build are illustrative placeholders for the design.

Reference information for research purposes. Not medical advice, and not a recommendation to use any compound. Many entries describe substances that are not approved for human use.

Related profiles

Gonadorelin Acetate

Clinical

Preserve natural testosterone via HPG axis activation

Gonadorelin Acetate is a synthetic decapeptide identical to endogenous gonadotropin-releasing hormone (GnRH), produced and secreted by the hypothalamus. It stimulates the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH), thereby supporting endogenous testosterone and estrogen production. It is used clinically to assess pituitary function, treat hypogonadism, support fertility, and is increasingly used alongside anabolic protocols to preserve testicular function.

0 RCT · 0 human · 0 preclinical

sexual

Human Chorionic Gonadotropin (HCG)

Clinical

The LH Mimic for Hormonal Restoration

Human Chorionic Gonadotropin (HCG) is a glycoprotein hormone naturally produced by the placenta during pregnancy, structurally similar to luteinizing hormone (LH). In clinical and research settings, it is used to stimulate testosterone production in men, support fertility, and maintain testicular function during or after anabolic steroid use. It acts directly on the gonads to mimic LH signaling, making it a cornerstone of hormonal restoration protocols.

0 RCT · 0 human · 0 preclinical

sexual

Human Menopausal Gonadotropin (HMG)

Clinical

Dual gonadotropin for fertility and testicular function

Human Menopausal Gonadotropin (HMG) is a purified preparation of gonadotropins extracted from the urine of postmenopausal women, containing both Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH) activity in approximately equal ratios. In clinical medicine it is used to stimulate ovulation in women and spermatogenesis in men, particularly those with hypogonadotropic hypogonadism. In performance and fertility contexts, HMG is used alongside or after hCG to restore or maintain testicular function, intratesticular testosterone production, and sperm output.

0 RCT · 0 human · 0 preclinical

sexual