NAD+ (Nicotinamide Riboside)

AMPK activator mimicking endurance exercise effects

AICAR (Acadesine) is a nucleoside analog and potent AMPK activator that mimics the cellular energy-depletion state, triggering a cascade of metabolic adaptations including enhanced fatty acid oxidation and mitochondrial biogenesis. It has been extensively studied for its ability to improve endurance performance, insulin sensitivity, and metabolic flexibility without physical exercise. Originally developed as a cardioprotective agent, it has attracted significant interest in the performance and longevity research communities.

Senolytic peptide targeting cellular senescence

FOXO4-DRI is a D-amino acid retro-inverso peptide designed to selectively induce apoptosis in senescent cells by disrupting the interaction between FOXO4 and p53. It belongs to a class of experimental senolytic compounds—agents that clear aged, dysfunctional 'zombie' cells from tissues. Research has been conducted primarily in mouse models, where it demonstrated improvements in fitness, fur density, kidney function, and lifespan metrics.

Master antioxidant for detox and cellular defense

Glutathione is a tripeptide antioxidant composed of glutamate, cysteine, and glycine that is naturally synthesized in virtually every cell of the body. It serves as the body's master antioxidant, neutralizing reactive oxygen species, supporting detoxification pathways, and maintaining redox homeostasis. Declining glutathione levels are associated with aging, chronic disease, and oxidative stress-related conditions.