149 compounds. Every one graded.

AMPK activator mimicking endurance exercise effects

AICAR (Acadesine) is a nucleoside analog and potent AMPK activator that mimics the cellular energy-depletion state, triggering a cascade of metabolic adaptations including enhanced fatty acid oxidation and mitochondrial biogenesis. It has been extensively studied for its ability to improve endurance performance, insulin sensitivity, and metabolic flexibility without physical exercise. Originally developed as a cardioprotective agent, it has attracted significant interest in the performance and longevity research communities.

Master antioxidant for detox and cellular defense

Glutathione is a tripeptide antioxidant composed of glutamate, cysteine, and glycine that is naturally synthesized in virtually every cell of the body. It serves as the body's master antioxidant, neutralizing reactive oxygen species, supporting detoxification pathways, and maintaining redox homeostasis. Declining glutathione levels are associated with aging, chronic disease, and oxidative stress-related conditions.

NAD+ precursor for cellular energy and repair

NAD+ precursor for cellular energy & DNA repair.

Senolytic peptide targeting cellular senescence

FOXO4-DRI is a D-amino acid retro-inverso peptide designed to selectively induce apoptosis in senescent cells by disrupting the interaction between FOXO4 and p53. It belongs to a class of experimental senolytic compounds—agents that clear aged, dysfunctional 'zombie' cells from tissues. Research has been conducted primarily in mouse models, where it demonstrated improvements in fitness, fur density, kidney function, and lifespan metrics.

Exercise mimetic targeting mitochondrial energy pathways

SLU-PP-322 is a synthetic small-molecule agonist of estrogen-related receptors (ERRα, ERRβ, and ERRγ) developed at Saint Louis University. It mimics the metabolic effects of sustained aerobic exercise at the cellular level, promoting mitochondrial biogenesis, fatty acid oxidation, and endurance capacity without physical activity. In preclinical animal studies, it has demonstrated significant improvements in exercise performance, fat metabolism, and cardiac function.