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AnimalOligopeptide-68 for cellular aging reversal

Oligopeptide-68 (Progeline)

Anti-senescence peptide that reduces progerin.

Overview

Interacts with farnesyl transferase and lamin A processing pathways, reducing pathological progerin accumulation.

Proposed mechanism

Oligopeptide-68 binds to nuclear lamins and reduces expression of progerin, a truncated lamin A protein that drives premature cellular aging.

What the evidence supports

Most data comes from preclinical animal studies. Human clinical trial evidence is limited or absent.

Graded Animal

Evidence drawn from in vivo animal models or in vitro systems. Mechanistically informative; translation to humans is unproven.

Key citations

Representative primary sources, including results that did not favour the compound.

  1. [1]

    Progeline anti-aging

    · DOI:10.1111/j.1473-2165.2012.00635.x · 2012

  2. [2]

    Progerin in aging skin

    · DOI:10.1111/j.1524-4725.2012.02531.x · 2012

  3. [3]

    Progeline anti-aging (2012)

    · · 0

  4. [4]

    Progerin in aging skin (2012)

    · · 0

Citation records in this build are illustrative placeholders for the design.

Reference information for research purposes. Not medical advice, and not a recommendation to use any compound. Many entries describe substances that are not approved for human use.

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