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Peptide Library

Peptide profile

Anti-aging Limited human

Tetrapeptide-7 (Rigin)

Tetrapeptide-7 for extracellular matrix repair

Compare Tetrapeptide-7 (Rigin) with other peptides →

Summary

Anti-inflammatory peptide for skin rejuvenation.

A tiny protein that calms skin and helps it look fresh.

Typical dose
2-4% concentration (often paired with Matrixyl) 1-2x daily
Route
Topical
Cycle length
Ongoing
Evidence
Limited human data

Mechanism

How it works

Rigin works like a two-handed tool — one hand reduces inflammation (calming skin), the other rebuilds collagen (restoring structure).

Tetrapeptide-7 is a synthetic peptide that mimics the endogenous protein SPARC, modulating interleukin production and extracellular matrix synthesis.

Tetrapeptide-7 is a synthetic peptide that mimics the endogenous protein SPARC, modulating interleukin production and extracellular matrix synthesis.

Reported in research

Benefits

  • Reduces skin inflammation
  • Stimulates collagen and fibronectin
  • Repairs sun-damaged skin
  • Improves skin density and elasticity
  • Calms red, puffy skin
  • Helps make collagen, which keeps skin strong
  • Fixes skin hurt by the sun
  • Makes skin firmer and bouncier

Context, not a prescription

Dosing

Typical range
2-4% concentration (often paired with Matrixyl) 1-2x daily (Topical)
Cycle length
Ongoing

Safety

Side effects & contraindications

Possible side effects

  • Minimal; very well tolerated
  • Mild irritation

Contraindications

  • Known peptide sensitivity

Research information, not medical advice. Always consult a licensed clinician before considering any peptide.

In depth

Full profile

What it does

Less swelling, firmer skin, smoother feel, and less sun damage.

How it works

Rigin works like a tool with two hands. One hand calms the skin. The other hand rebuilds collagen to make skin strong.

It turns down the signals that cause skin swelling. At the same time, it tells skin cells to make more collagen and other building blocks.

What to expect

You can see changes in about 4-6 weeks.

  • Weeks 2-3: Less redness and less touchy skin.
  • Weeks 4-6: Smoother and firmer skin.
  • Weeks 8-10: Fewer tiny lines and less sun damage.

Good to know

  • Test it on a small skin spot first

Staying safe

  • Almost none; very gentle on skin

Avoid if you have:

  • People who react badly to peptides

Overview

Reduced inflammation, firmer skin, improved texture, less sun damage.

How it works

Rigin works like a two-handed tool — one hand reduces inflammation (calming skin), the other rebuilds collagen (restoring structure).

Downregulates IL-1α, IL-6, and TNF-α while upregulating collagen and fibronectin synthesis in fibroblasts.

Onset & timeline

Visible improvement at 4-6 weeks.

  • Weeks 2-3: Reduced redness and sensitivity.
  • Weeks 4-6: Improved skin texture and firmness.
  • Weeks 8-10: Reduced fine lines and sun damage.

Getting the most from it

  • Patch test first

Common side effects

  • Minimal; very well tolerated

Mechanism of action

Tetrapeptide-7 is a synthetic peptide that mimics the endogenous protein SPARC, modulating interleukin production and extracellular matrix synthesis.

Downregulates IL-1α, IL-6, and TNF-α while upregulating collagen and fibronectin synthesis in fibroblasts.

Pharmacodynamics

Visible improvement at 4-6 weeks.

Reduced inflammation, firmer skin, improved texture, less sun damage.

Timeline

  • Weeks 2-3: Reduced redness and sensitivity.
  • Weeks 4-6: Improved skin texture and firmness.
  • Weeks 8-10: Reduced fine lines and sun damage.

Comparisons

  • Rigin — effectiveness High, safety Excellent, cost $$, Very Easy to use
  • Matrixyl — effectiveness High, safety Excellent, cost $$, Very Easy to use

Adverse effects

Common:

  • Minimal; very well tolerated

Rare:

  • Mild irritation

Contraindications & risk mitigation

Contraindicated in:

  • Known peptide sensitivity
  • Patch test first

Qué hace

Menos hinchazón, piel más firme, textura más suave y menor daño solar.

Cómo funciona

Rigin funciona como una herramienta con dos manos. Una mano calma la piel. La otra mano reconstruye el colágeno para fortalecerla.

Reduce las señales que causan hinchazón en la piel. Al mismo tiempo, le indica a las células cutáneas que produzcan más colágeno y otros componentes estructurales.

Qué esperar

Puedes notar cambios en unas 4-6 semanas.

  • Semanas 2-3: Menos enrojecimiento y piel menos sensible.
  • Semanas 4-6: Piel más suave y firme.
  • Semanas 8-10: Menos líneas finas y menos daño solar.

Bueno saber

  • Prueba una pequeña zona de la piel primero

Manteniéndose seguro

  • Casi ninguno; muy suave con la piel

Evitar si tienes:

  • Personas que reaccionan mal a los péptidos

Descripción general

Inflamación reducida, piel más firme, textura mejorada, menor daño solar.

Cómo funciona

Rigin funciona como una herramienta de dos manos: una mano reduce la inflamación (calmando la piel) y la otra reconstruye el colágeno (restaurando la estructura).

Disminuye la IL-1α, IL-6 y TNF-α, mientras aumenta la síntesis de colágeno y fibronectina en los fibroblastos.

Inicio y cronología

Mejora visible a las 4-6 semanas.

  • Semanas 2-3: Reducción del enrojecimiento y la sensibilidad.
  • Semanas 4-6: Mejora de la textura y firmeza de la piel.
  • Semanas 8-10: Reducción de líneas finas y daño solar.

Cómo aprovecharlo al máximo

  • Realizar prueba de parche primero

Efectos secundarios comunes

  • Mínimos; muy bien tolerado

Mecanismo de acción

El Tetrapeptide-7 es un péptido sintético que imita la proteína endógena SPARC, modulando la producción de interleucinas y la síntesis de la matriz extracelular.

Disminuye la IL-1α, IL-6 y TNF-α, mientras aumenta la síntesis de colágeno y fibronectina en los fibroblastos.

Farmacodinamia

Mejora visible a las 4-6 semanas.

Inflamación reducida, piel más firme, textura mejorada, menor daño solar.

Cronología

  • Semanas 2-3: Reducción del enrojecimiento y la sensibilidad.
  • Semanas 4-6: Mejora de la textura y firmeza de la piel.
  • Semanas 8-10: Reducción de líneas finas y daño solar.

Comparaciones

  • Rigin — efectividad Alta, seguridad Excelente, costo $$, Muy fácil de usar
  • Matrixyl — efectividad Alta, seguridad Excelente, costo $$, Muy fácil de usar

Efectos adversos

Comunes:

  • Mínimos; muy bien tolerado

Raros:

  • Irritación leve

Contraindicaciones y mitigación de riesgos

Contraindicado en:

  • Sensibilidad conocida a péptidos
  • Realizar prueba de parche primero

Reference data

Specifications

Route
Topical
Cycle length
Ongoing

FAQ

Common questions

Is Rigin the same as Matrixyl?

No, Matrixyl is pentapeptide-4. Rigin is tetrapeptide-7. They work synergistically and are often combined.

Is it good for sensitive skin?

Yes, because it reduces inflammation, it's excellent for sensitive or rosacea-prone skin.

What is the evidence level?

This compound is classified as Limited human data. Some human data exists but trials are small, short-term, or not yet replicated.

Research

Research & sources

Limited human

Current evidence for Tetrapeptide-7 (Rigin) is rated as Limited human data. Limited human data is available.

  1. 1. Tetrapeptide-7 in skin repair (2005) — DOI:10.1111/j.1468-2494.2005.00245.x
  2. 2. SPARC peptide analogs (2019) — DOI:10.1111/jocd.12703
  3. 3. Tetrapeptide-7 in skin repair (2005)
  4. 4. SPARC peptide analogs (2019)