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Human-limitedTetrapeptide-7 for extracellular matrix repair

Tetrapeptide-7 (Rigin)

Anti-inflammatory peptide for skin rejuvenation.

Overview

Downregulates IL-1α, IL-6, and TNF-α while upregulating collagen and fibronectin synthesis in fibroblasts.

Proposed mechanism

Tetrapeptide-7 is a synthetic peptide that mimics the endogenous protein SPARC, modulating interleukin production and extracellular matrix synthesis.

What the evidence supports

Human data exists but the trials are small, short-term, or not yet replicated.

Graded Human-limited

Human data that exists but is thin: open-label work, single-arm studies, small cohorts, or observational follow-up without randomisation.

Key citations

Representative primary sources, including results that did not favour the compound.

  1. [1]

    Tetrapeptide-7 in skin repair

    · DOI:10.1111/j.1468-2494.2005.00245.x · 2005

  2. [2]

    SPARC peptide analogs

    · DOI:10.1111/jocd.12703 · 2019

  3. [3]

    Tetrapeptide-7 in skin repair (2005)

    · · 0

  4. [4]

    SPARC peptide analogs (2019)

    · · 0

Citation records in this build are illustrative placeholders for the design.

Reference information for research purposes. Not medical advice, and not a recommendation to use any compound. Many entries describe substances that are not approved for human use.

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