Overview
Activates PPAR receptors and aquaporin gene expression in the epidermis.
Proposed mechanism
Oligopeptide-177 is a marine-derived peptide that upregulates aquaporin-3 (water channels) and ceramide synthesis in keratinocytes.
What the evidence supports
Human data exists but the trials are small, short-term, or not yet replicated.
Graded Human-limited
Human data that exists but is thin: open-label work, single-arm studies, small cohorts, or observational follow-up without randomisation.
Key citations
Representative primary sources, including results that did not favour the compound.
- [1]
Marine peptides for hydration
· DOI:10.1111/jocd.12893 · 2019
- [2]
Aquaporin-3 in aging
· DOI:10.1111/ics.12588 · 2020
- [3]
Marine peptides for hydration (2019)
· · 0
- [4]
Aquaporin-3 in aging (2020)
· · 0
Citation records in this build are illustrative placeholders for the design.
Reference information for research purposes. Not medical advice, and not a recommendation to use any compound. Many entries describe substances that are not approved for human use.