Overview
Penetrates stratum corneum, activates gene expression for ceramide synthase enzymes.
Proposed mechanism
Hexapeptide-11 upregulates serine palmitoyltransferase, the rate-limiting enzyme in ceramide synthesis, restoring skin barrier lipids.
What the evidence supports
Human data exists but the trials are small, short-term, or not yet replicated.
Graded Human-limited
Human data that exists but is thin: open-label work, single-arm studies, small cohorts, or observational follow-up without randomisation.
Key citations
Representative primary sources, including results that did not favour the compound.
- [1]
Ceramide peptides in skin
· DOI:10.1111/j.1473-2165.2011.00552.x · 2011
- [2]
Peptide ceramide regulators
· DOI:10.1111/jocd.12962 · 2019
- [3]
Ceramide peptides in skin (2011)
· · 0
- [4]
Peptide ceramide regulators (2019)
· · 0
Citation records in this build are illustrative placeholders for the design.
Reference information for research purposes. Not medical advice, and not a recommendation to use any compound. Many entries describe substances that are not approved for human use.