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Human-limitedMelanocortin receptor agonist for sexual function

PT-141 (Bremelanotide)

Melanocortin agonist for sexual health & libido.

Overview

Activates MC3R and MC4R receptors in the hypothalamus and limbic system.

Proposed mechanism

Cyclic heptapeptide melanocortin analog activating melanocortin receptors in the CNS for erectile response independent of visual stimulation.

What the evidence supports

Human data exists but the trials are small, short-term, or not yet replicated.

Graded Human-limited

Human data that exists but is thin: open-label work, single-arm studies, small cohorts, or observational follow-up without randomisation.

Key citations

Representative primary sources, including results that did not favour the compound.

  1. [1]

    Bremelanotide for HSDD

    · DOI:10.1016/j.jsxm.2019.01.009 · 2019

  2. [2]

    Melanocortins and sexual function

    · DOI:10.1038/s41443-018-0044-4 · 2018

  3. [3]

    Bremelanotide for HSDD (2019)

    · · 0

  4. [4]

    Melanocortins and sexual function (2018)

    · · 0

Citation records in this build are illustrative placeholders for the design.

Reference information for research purposes. Not medical advice, and not a recommendation to use any compound. Many entries describe substances that are not approved for human use.

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