Peptide profile
Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-ake)
Snake venom analog for expression lines
Compare Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-ake) with other peptides →Summary
A peptide like snake venom that relaxes wrinkles from facial movements.
- Typical dose
- 2-5% concentration 1-2x daily
- Route
- Topical
- Cycle length
- Ongoing
- Evidence
- Limited human data
Mechanism
How it works
Syn-ake works like a gentle 'volume down' button for facial muscles — it reduces contractions without freezing movement.
Syn-ake is a synthetic tripeptide that mimics Waglerin-1 (from snake venom), blocking nicotinic acetylcholine receptors at neuromuscular junctions.
Reported in research
Benefits
- Helps face muscles relax
- Smooths lines on forehead and around eyes
- Works a bit like Botox but with no poison
- Gentle and wears off over time
Context, not a prescription
Dosing
- Typical range
- 2-5% concentration 1-2x daily (Topical)
- Cycle length
- Ongoing
Safety
Side effects & contraindications
Possible side effects
- Minimal; well tolerated
- Mild tingling
- Contact dermatitis
Contraindications
- Known peptide sensitivity
Research information, not medical advice. Always consult a licensed clinician before considering any peptide.
In depth
Full profile
What it does
Softer facial looks and shallower movement wrinkles.
How it works
Syn-ake works like a soft 'turn down the volume' button for face muscles. It calms them without freezing your face.
It gently blocks the signal that makes muscles tighten. So the muscles stay calmer.
What to expect
You can see it working in about 3-4 weeks.
- Weeks 2-3: Forehead lines start to soften a little.
- Weeks 4-6: Fewer lines near your eyes.
- Weeks 8-10: Smoothest skin you will see.
Good to know
- Test it on a small skin spot first
- Keep it out of your eyes
Staying safe
- Almost none; very easy on skin
- A light tingle
Avoid if you have:
- People who react badly to peptides
Mechanism of action
Syn-ake is a synthetic tripeptide that mimics Waglerin-1 (from snake venom), blocking nicotinic acetylcholine receptors at neuromuscular junctions.
Competitively binds to nACh receptors, reducing acetylcholine's ability to trigger muscle contraction.
Pharmacodynamics
Visible improvement at 3-4 weeks.
Softer facial expressions, reduced dynamic wrinkle depth.
Timeline
- Weeks 2-3: Subtle relaxation of forehead lines.
- Weeks 4-6: Reduced crow's feet.
- Weeks 8-10: Maximum smoothing effect.
Comparisons
- Syn-ake — effectiveness Moderate, safety Excellent, cost $$, Very Easy to use
- Argireline — effectiveness Moderate, safety Excellent, cost $, Very Easy to use
Adverse effects
Common:
- Minimal; well tolerated
- Mild tingling
Rare:
- Contact dermatitis
Contraindications & risk mitigation
Contraindicated in:
- Known peptide sensitivity
- Patch test first
- Avoid eye contact
Qué hace
Rostro más relajado y arrugas de movimiento menos profundas.
Cómo funciona
Syn-ake funciona como un botón suave de 'bajar el volumen' para los músculos de la cara. Los calma sin congelar tu rostro.
Bloquea suavemente la señal que hace que los músculos se tensen. Así los músculos se mantienen más relajados.
Qué esperar
Puedes ver que funciona en unas 3-4 semanas.
- Semanas 2-3: Las líneas de la frente comienzan a suavizarse un poco.
- Semanas 4-6: Menos líneas cerca de tus ojos.
- Semanas 8-10: La piel más lisa que verás.
Bueno saber
- Pruébalo primero en una pequeña zona de la piel
- Manténlo fuera de tus ojos
Manteniéndose seguro
- Casi ninguno; muy suave para la piel
- Un ligero hormigueo
Evitar si tienes:
- Personas que reaccionan mal a los péptidos
Mecanismo de acción
Syn-ake es un tripéptido sintético que imita a la Waglerin-1 (del veneno de serpiente), bloqueando los receptores nicotínicos de acetilcolina en las uniones neuromusculares.
Se une competitivamente a los receptores nACh, reduciendo la capacidad de la acetilcolina para desencadenar la contracción muscular.
Farmacodinamia
Mejora visible a las 3-4 semanas.
Expresiones faciales más suaves, reducción de la profundidad de las arrugas dinámicas.
Cronología
- Semanas 2-3: Relajación sutil de las líneas de la frente.
- Semanas 4-6: Reducción de las patas de gallo.
- Semanas 8-10: Efecto máximo de suavizado.
Comparaciones
- Syn-ake — efectividad Moderada, seguridad Excelente, costo $$, Muy fácil de usar
- Argireline — efectividad Moderada, seguridad Excelente, costo $, Muy fácil de usar
Efectos adversos
Comunes:
- Mínimos; bien tolerado
- Hormigueo leve
Raros:
- Dermatitis de contacto
Contraindicaciones y mitigación de riesgos
Contraindicado en:
- Sensibilidad conocida a péptidos
- Realizar prueba de parche primero
- Evitar el contacto con los ojos
Reference data
Specifications
- Route
- Topical
- Cycle length
- Ongoing
FAQ
Common questions
Is Syn-ake better than Argireline?
Different mechanisms; Syn-ake works on nACh receptors, Argireline on SNARE. Both can be used together.
Does it actually contain snake venom?
No, it's a synthetic peptide that mimics the mechanism of snake venom, not the venom itself.
What is the evidence level?
This compound is classified as Limited human data. Some human data exists but trials are small, short-term, or not yet replicated.
Research
Research & sources
Current evidence for Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-ake) is rated as Limited human data. Limited human data is available.
- 1. Syn-ake clinical study (2006) — DOI:10.1111/j.1473-2165.2006.00233.x
- 2. Neuropeptide cosmetics (2017) — DOI:10.1111/jocd.12404
- 3. Syn-ake clinical study (2006)
- 4. Neuropeptide cosmetics (2017)